Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin

Karoline Sidelmann Brinch, Paul M Tulkens, Francoise Van Bambeke, Niels Frimodt-Møller, Niels Høiby, Hans-Henrik Kristensen

37 Citations (Scopus)

Abstract

Staphylococcus aureus survives inside eukaryotic cells. Our objective was to assess the activity of NZ2114, a novel peptidic antibiotic, against intracellular S. aureus in comparison with established antistaphylococcal agents acting on the bacterial envelope with a distinct mechanism.
Original languageEnglish
JournalJournal of Antimicrobial Chemotherapy
Volume65
Issue number8
Pages (from-to)1720-4
Number of pages5
ISSN0305-7453
DOIs
Publication statusPublished - 1 Aug 2010

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