Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Urothelial cell senescence is not linked with telomere shortening

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Demineralized bone matrix and human cancellous bone enhance fixation of porous-coated titanium implants in sheep

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The effects of glucocorticoid on microarchitecture, collagen, mineral and mechanical properties of sheep femur cortical bone

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reply

    Research output: Contribution to journalLetterResearchpeer-review

  2. Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-Analysis

    Research output: Contribution to journalReviewResearchpeer-review

  3. IBD metabonomics predicts phenotype, disease course, and treatment response

    Research output: Contribution to journalReviewResearchpeer-review

  4. Telomere dysfunction instigates inflammation in inflammatory bowel disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Acute Fluctuations in Plasma Glucose Affect Echocardiographic-Derived Measures of Systolic Function in Patients with Type 1 Diabetes

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

View graph of relations

Disruption of normal barrier function is a fundamental factor in the pathogenesis of inflammatory bowel disease, which includes increased epithelial cell death, modified mucus configuration, altered expression and distribution of tight junction proteins, along with a decreased expression of antimicrobial peptides. Inflammatory bowel disease is associated with life-long morbidity for affected patients, and both the incidence and prevalence is increasing globally, resulting in substantial economic strain for society. Mucosal healing and re-establishment of barrier integrity are associated with clinical remission, as well as with an improved patient outcome. Hence, these factors are vital treatment goals, which conventionally are achieved by a range of medical treatments, although none are effective in all patients, resulting in several patients still requiring surgery at some point. Therefore, novel treatment strategies to accomplish mucosal healing and to re-establish normal barrier integrity in inflammatory bowel disease are warranted, and luminal stem cell-based approaches might have an intriguing potential. Transplantation of in vitro expanded intestinal epithelial stem cells derived either directly from mucosal biopsies or from directed differentiation of human pluripotent stem cells may constitute complementary treatment options for patients with mucosal damage, as intestinal epithelial stem cells are multipotent and may give rise to all epithelial cell types of the intestine. This review provides the reader with a comprehensive state-of-the-art overview of the intestinal barrier's role in healthy and diseased states, discussing the clinical application of stem cell-based approaches to accomplish mucosal healing in inflammatory bowel disease.

Original languageEnglish
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume12
Issue number4
Pages (from-to)923-935
Number of pages13
ISSN1932-6254
DOIs
Publication statusPublished - Apr 2018

ID: 56371065