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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Interventions targeted at oxidatively generated modifications of nucleic acids focused on urine and plasma markers

Research output: Contribution to journalReviewResearchpeer-review

  1. Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Oxidatively generated modifications to nucleic acids in vivo: Measurement in urine and plasma

    Research output: Contribution to journalReviewResearchpeer-review

  3. The Effect of Different Training Intensities on Oxidatively Generated Modifications of Nucleic Acids: A Randomized, Controlled Trial

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. RNA oxidation and iron levels in patients with diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

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Oxidative stress is associated with the development and progression of numerous diseases. However, targeting oxidative stress has not been established in the clinical management of any disease. Several methods and markers are available to measure oxidative stress, including direct measurement of free radicals, antioxidants, redox balance, and oxidative modifications of cellular macromolecules. Oxidatively generated nucleic acid modifications have attracted much interest due to the pre-mutagenic oxidative modification of DNA into 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), associated with cancer development. During the last decade, the perception of RNA has changed from that of a ‘silent messenger’ to an ‘active contributor’, and, parallelly oxidatively generated RNA modifications measured as 8-oxo-7,8-dihydro-guanosine (8-oxoGuo), has been demonstrated as a prognostic factor for all-caused and cardiovascular related mortality in patients with type 2 diabetes. Several attempts have been made to modify the amount of oxidative nucleic acid modifications. Thus, this review aims to introduce researchers to the measurement of oxidatively generated nucleic acid modifications as well as critically review previous attempts and provide future directions for targeting oxidatively generated nucleic acid modifications.

Original languageEnglish
JournalFree Radical Biology & Medicine
Volume145
Pages (from-to)256-283
Number of pages28
ISSN0891-5849
DOIs
Publication statusPublished - Dec 2019

Bibliographical note

Copyright © 2019 Elsevier Inc. All rights reserved.

    Research areas

  • 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydro-guanosine, Clinical trials, Intervention, Oxidative nucleic acid modifications, Oxidative stress

ID: 58036901