Interstitial cells of Cajal in human gut and gastrointestinal disease

J M Vanderwinden; J J Rumessen

doi:10.1002/(SICI)1097-0029(19991201)47:5<344::AID-JEMT6>3.0.CO;2-1

Interstitial cells of Cajal in human gut and gastrointestinal disease

J M Vanderwinden, J J Rumessen

188 Citations (Scopus)

Abstract

This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastrointestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in achalasia of cardia, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction, Hirschsprung's disease, inflammatory bowel diseases, slow transit constipation, and some other disorders of GI motility as well as in gastrointestinal stromal tumors are reviewed, with emphasis on the place of ICC in the pathophysiology of disease.

Original language	English
Journal	Microscopy Research and Technique
Volume	47
Issue number	5
Pages (from-to)	344-60
Number of pages	17
ISSN	1059-910X
DOIs	https://doi.org/10.1002/(SICI)1097-0029(19991201)47:5<344::AID-JEMT6>3.0.CO;2-1
Publication status	Published - 1 Dec 1999

Keywords

Adult
Child
Colitis, Ulcerative
Digestive System
Fetus
Gastrointestinal Diseases
Hirschsprung Disease
Humans
Ileum
Immunohistochemistry
Infant
Intestines
Microscopy, Confocal
Microscopy, Electron
Muscle, Smooth
Proto-Oncogene Proteins c-kit
Stomach

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10.1002/(SICI)1097-0029(19991201)47:5<344::AID-JEMT6>3.0.CO;2-1

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title = "Interstitial cells of Cajal in human gut and gastrointestinal disease",

abstract = "This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastrointestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in achalasia of cardia, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction, Hirschsprung's disease, inflammatory bowel diseases, slow transit constipation, and some other disorders of GI motility as well as in gastrointestinal stromal tumors are reviewed, with emphasis on the place of ICC in the pathophysiology of disease.",

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AU - Rumessen, J J

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N2 - This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastrointestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in achalasia of cardia, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction, Hirschsprung's disease, inflammatory bowel diseases, slow transit constipation, and some other disorders of GI motility as well as in gastrointestinal stromal tumors are reviewed, with emphasis on the place of ICC in the pathophysiology of disease.

AB - This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastrointestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in achalasia of cardia, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction, Hirschsprung's disease, inflammatory bowel diseases, slow transit constipation, and some other disorders of GI motility as well as in gastrointestinal stromal tumors are reviewed, with emphasis on the place of ICC in the pathophysiology of disease.

KW - Adult

KW - Child

KW - Colitis, Ulcerative

KW - Digestive System

KW - Fetus

KW - Gastrointestinal Diseases

KW - Hirschsprung Disease

KW - Humans

KW - Ileum

KW - Immunohistochemistry

KW - Infant

KW - Intestines

KW - Microscopy, Confocal

KW - Microscopy, Electron

KW - Muscle, Smooth

KW - Proto-Oncogene Proteins c-kit

KW - Stomach

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DO - 10.1002/(SICI)1097-0029(19991201)47:5<344::AID-JEMT6>3.0.CO;2-1

M3 - Journal article

C2 - 10602294

SN - 1059-910X

VL - 47

SP - 344

EP - 360

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

IS - 5

ER -

Interstitial cells of Cajal in human gut and gastrointestinal disease

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Keywords

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