Interstitial cells of Cajal in human colon and in Hirschsprung's disease

J M Vanderwinden; J J Rumessen; H Liu; D Descamps; M H De Laet; J J Vanderhaeghen

Interstitial cells of Cajal in human colon and in Hirschsprung's disease

J M Vanderwinden, J J Rumessen, H Liu, D Descamps, M H De Laet, J J Vanderhaeghen

280 Citations (Scopus)

Abstract

Subpopulations of interstitial cells of Cajal are regarded as the source of spontaneous slow waves of the gut musculature (pacemaker cells). Their ontogeny remains unclear, but a role of the tyrosine kinase receptor c-kit in their development has recently been recognized. This study examined the interstitial cells in the human colon and in Hirschsprung's disease (aganglionosis).

Original language	English
Journal	Gastroenterology
Volume	111
Issue number	4
Pages (from-to)	901-10
Number of pages	10
ISSN	0016-5085
Publication status	Published - Oct 1996

Keywords

Child, Preschool
Colon
Female
Hirschsprung Disease
Humans
Infant
Infant, Newborn
Male
Proto-Oncogene Proteins c-kit
Stem Cell Factor

Cite this

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abstract = "Subpopulations of interstitial cells of Cajal are regarded as the source of spontaneous slow waves of the gut musculature (pacemaker cells). Their ontogeny remains unclear, but a role of the tyrosine kinase receptor c-kit in their development has recently been recognized. This study examined the interstitial cells in the human colon and in Hirschsprung's disease (aganglionosis).",

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T1 - Interstitial cells of Cajal in human colon and in Hirschsprung's disease

AU - Vanderwinden, J M

AU - Rumessen, J J

AU - Liu, H

AU - Descamps, D

AU - De Laet, M H

AU - Vanderhaeghen, J J

PY - 1996/10

Y1 - 1996/10

N2 - Subpopulations of interstitial cells of Cajal are regarded as the source of spontaneous slow waves of the gut musculature (pacemaker cells). Their ontogeny remains unclear, but a role of the tyrosine kinase receptor c-kit in their development has recently been recognized. This study examined the interstitial cells in the human colon and in Hirschsprung's disease (aganglionosis).

AB - Subpopulations of interstitial cells of Cajal are regarded as the source of spontaneous slow waves of the gut musculature (pacemaker cells). Their ontogeny remains unclear, but a role of the tyrosine kinase receptor c-kit in their development has recently been recognized. This study examined the interstitial cells in the human colon and in Hirschsprung's disease (aganglionosis).

KW - Child, Preschool

KW - Colon

KW - Female

KW - Hirschsprung Disease

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Proto-Oncogene Proteins c-kit

KW - Stem Cell Factor

UR - https://www.scopus.com/pages/publications/0029793340

M3 - Journal article

C2 - 8831584

SN - 0016-5085

VL - 111

SP - 901

EP - 910

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Interstitial cells of Cajal in human colon and in Hirschsprung's disease

Abstract

Keywords

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