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International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

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Harvard

van Dam, P-J, van der Stok, EP, Teuwen, L-A, Van den Eynden, GG, Illemann, M, Frentzas, S, Majeed, AW, Eefsen, RL, Coebergh van den Braak, RRJ, Lazaris, A, Fernandez, MC, Galjart, B, Laerum, OD, Rayes, R, Grünhagen, DJ, Van de Paer, M, Sucaet, Y, Mudhar, HS, Schvimer, M, Nyström, H, Kockx, M, Bird, NC, Vidal-Vanaclocha, F, Metrakos, P, Simoneau, E, Verhoef, C, Dirix, LY, Van Laere, S, Gao, Z-H, Brodt, P, Reynolds, AR & Vermeulen, PB 2017, 'International consensus guidelines for scoring the histopathological growth patterns of liver metastasis' B J C, vol. 117, no. 10, pp. 1427-1441. https://doi.org/10.1038/bjc.2017.334

APA

van Dam, P-J., van der Stok, E. P., Teuwen, L-A., Van den Eynden, G. G., Illemann, M., Frentzas, S., ... Vermeulen, P. B. (2017). International consensus guidelines for scoring the histopathological growth patterns of liver metastasis. B J C, 117(10), 1427-1441. https://doi.org/10.1038/bjc.2017.334

CBE

van Dam P-J, van der Stok EP, Teuwen L-A, Van den Eynden GG, Illemann M, Frentzas S, Majeed AW, Eefsen RL, Coebergh van den Braak RRJ, Lazaris A, Fernandez MC, Galjart B, Laerum OD, Rayes R, Grünhagen DJ, Van de Paer M, Sucaet Y, Mudhar HS, Schvimer M, Nyström H, Kockx M, Bird NC, Vidal-Vanaclocha F, Metrakos P, Simoneau E, Verhoef C, Dirix LY, Van Laere S, Gao Z-H, Brodt P, Reynolds AR, Vermeulen PB. 2017. International consensus guidelines for scoring the histopathological growth patterns of liver metastasis. B J C. 117(10):1427-1441. https://doi.org/10.1038/bjc.2017.334

MLA

Vancouver

van Dam P-J, van der Stok EP, Teuwen L-A, Van den Eynden GG, Illemann M, Frentzas S et al. International consensus guidelines for scoring the histopathological growth patterns of liver metastasis. B J C. 2017 Nov 7;117(10):1427-1441. https://doi.org/10.1038/bjc.2017.334

Author

van Dam, Pieter-Jan ; van der Stok, Eric P ; Teuwen, Laure-Anne ; Van den Eynden, Gert G ; Illemann, Martin ; Frentzas, Sophia ; Majeed, Ali W ; Eefsen, Rikke L ; Coebergh van den Braak, Robert R J ; Lazaris, Anthoula ; Fernandez, Maria Celia ; Galjart, Boris ; Laerum, Ole Didrik ; Rayes, Roni ; Grünhagen, Dirk J ; Van de Paer, Michelle ; Sucaet, Yves ; Mudhar, Hardeep Singh ; Schvimer, Michael ; Nyström, Hanna ; Kockx, Mark ; Bird, Nigel C ; Vidal-Vanaclocha, Fernando ; Metrakos, Peter ; Simoneau, Eve ; Verhoef, Cornelis ; Dirix, Luc Y ; Van Laere, Steven ; Gao, Zu-Hua ; Brodt, Pnina ; Reynolds, Andrew R ; Vermeulen, Peter B. / International consensus guidelines for scoring the histopathological growth patterns of liver metastasis. In: B J C. 2017 ; Vol. 117, No. 10. pp. 1427-1441.

Bibtex

@article{f1fbf8ffbce74d9992b68305ba6e6461,
title = "International consensus guidelines for scoring the histopathological growth patterns of liver metastasis",
abstract = "BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.",
keywords = "Humans, Liver Neoplasms, Neoplasm Metastasis, Journal Article, Practice Guideline",
author = "{van Dam}, Pieter-Jan and {van der Stok}, {Eric P} and Laure-Anne Teuwen and {Van den Eynden}, {Gert G} and Martin Illemann and Sophia Frentzas and Majeed, {Ali W} and Eefsen, {Rikke L} and {Coebergh van den Braak}, {Robert R J} and Anthoula Lazaris and Fernandez, {Maria Celia} and Boris Galjart and Laerum, {Ole Didrik} and Roni Rayes and Gr{\"u}nhagen, {Dirk J} and {Van de Paer}, Michelle and Yves Sucaet and Mudhar, {Hardeep Singh} and Michael Schvimer and Hanna Nystr{\"o}m and Mark Kockx and Bird, {Nigel C} and Fernando Vidal-Vanaclocha and Peter Metrakos and Eve Simoneau and Cornelis Verhoef and Dirix, {Luc Y} and {Van Laere}, Steven and Zu-Hua Gao and Pnina Brodt and Reynolds, {Andrew R} and Vermeulen, {Peter B}",
year = "2017",
month = "11",
day = "7",
doi = "10.1038/bjc.2017.334",
language = "English",
volume = "117",
pages = "1427--1441",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

AU - van Dam, Pieter-Jan

AU - van der Stok, Eric P

AU - Teuwen, Laure-Anne

AU - Van den Eynden, Gert G

AU - Illemann, Martin

AU - Frentzas, Sophia

AU - Majeed, Ali W

AU - Eefsen, Rikke L

AU - Coebergh van den Braak, Robert R J

AU - Lazaris, Anthoula

AU - Fernandez, Maria Celia

AU - Galjart, Boris

AU - Laerum, Ole Didrik

AU - Rayes, Roni

AU - Grünhagen, Dirk J

AU - Van de Paer, Michelle

AU - Sucaet, Yves

AU - Mudhar, Hardeep Singh

AU - Schvimer, Michael

AU - Nyström, Hanna

AU - Kockx, Mark

AU - Bird, Nigel C

AU - Vidal-Vanaclocha, Fernando

AU - Metrakos, Peter

AU - Simoneau, Eve

AU - Verhoef, Cornelis

AU - Dirix, Luc Y

AU - Van Laere, Steven

AU - Gao, Zu-Hua

AU - Brodt, Pnina

AU - Reynolds, Andrew R

AU - Vermeulen, Peter B

PY - 2017/11/7

Y1 - 2017/11/7

N2 - BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.

AB - BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.

KW - Humans

KW - Liver Neoplasms

KW - Neoplasm Metastasis

KW - Journal Article

KW - Practice Guideline

U2 - 10.1038/bjc.2017.334

DO - 10.1038/bjc.2017.334

M3 - Journal article

VL - 117

SP - 1427

EP - 1441

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 10

ER -

ID: 52667780