Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

Research output: Contribution to journalJournal articleResearchpeer-review

  1. CO-HEP; Copenhagen Hepatitis C Program

    Project: Types of projectsProject

  1. Altered balance between collagen formation and degradation after successful direct-acting antiviral therapy of chronic hepatitis C

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hepatitis E during pregnancy: Maternal and foetal case-fatality rates and adverse outcomes—A systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Low compliance with hepatocellular carcinoma screening guidelines in hepatitis B/C virus co-infected HIV patients with cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hepatocellular carcinoma in patients with chronic hepatitis C and cirrhosis in Denmark: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The experience of pregnancy among women living with HIV in Nordic countries: A qualitative narrative enquiry

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reply

    Research output: Contribution to journalLetterResearchpeer-review

  3. Testing Denmark: a Danish Nationwide Surveillance Study of COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Summary.  Twenty-five per cent of individuals infected with hepatitis C virus (HCV) are able to clear HCV spontaneously. Differences in host genetics are believed to affect the outcome of HCV infection. We analysed an exonic, a promoter and an intronic single nucleotide polymorphism (SNP) of the interferon-λ3 coding interleukin (IL)-28B gene to study the relationship between IL28B SNPs and outcome of HCV infection. Among 206 HIV-1-infected Europeans with evidence of HCV infection, 47 (23%) individuals had cleared HCV and 159 (77%) had developed chronic infection. The exonic rs8103142 CT, the promoter rs12979860 CT and the intronic rs11881222 AG genotypes were associated with a decreased HCV clearance rate with adjusted odds ratios (aOR) of 0.3 (95% CI, 0.1-0.7), 0.4 (95% CI, 0.2-0.8) and 0.4 (95% CI, 0.2-0.8), respectively. The haplotype block TCG CTA was associated with a decreased HCV clearance rate (aOR 0.4, 95% CI, 0.2-0.8). Further, we found significant differences in HCV RNA levels among individuals chronically infected with HCV genotype 1 for rs8103142 and rs12979860 (P ≤ 0.05). Chronically infected individuals with HCV genotype 3 and with the favourable haplotype block CTA CTA had higher median HCV RNA levels than individuals with unfavourable haplotype blocks (P ≤ 0.05). Our findings suggest that IL28B may account for some differences in HCV outcome but that other factors including the viral genotype, host genetics and the host-virus interaction are likely to influence the outcome of HCV infection.
Original languageEnglish
JournalJournal of Viral Hepatitis
Volume18
Issue number4
Pages (from-to)e66-e74
DOIs
Publication statusPublished - Apr 2011

ID: 32572820