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Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS)

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von Conta, Jill ; Kasten, Florian H ; Ćurčić-Blake, Branislava ; Aleman, André ; Thielscher, Axel ; Herrmann, Christoph S. / Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS). In: Scientific Reports. 2021 ; Vol. 11, No. 1. pp. 1-12.

Bibtex

@article{56f210fb07d747948277c69ed7a639e8,
title = "Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS)",
abstract = "Transcranial temporal interference stimulation (tTIS) is a novel non-invasive brain stimulation technique for electrical stimulation of neurons at depth. Deep brain regions are generally small in size, making precise targeting a necessity. The variability of electric fields across individual subjects resulting from the same tTIS montages is unknown so far and may be of major concern for precise tTIS targeting. Therefore, the aim of the current study is to investigate the variability of the electric fields due to tTIS across 25 subjects. To this end, the electric fields of different electrode montages consisting of two electrode pairs with different center frequencies were simulated in order to target selected regions-of-interest (ROIs) with tTIS. Moreover, we set out to compare the electric fields of tTIS with the electric fields of conventional tACS. The latter were also based on two electrode pairs, which, however, were driven in phase at a common frequency. Our results showed that the electric field strengths inside the ROIs (left hippocampus, left motor area and thalamus) during tTIS are variable on single subject level. In addition, tTIS stimulates more focally as compared to tACS with much weaker co-stimulation of cortical areas close to the stimulation electrodes. Electric fields inside the ROI were, however, comparable for both methods. Overall, our results emphasize the potential benefits of tTIS for the stimulation of deep targets, over conventional tACS. However, they also indicate a need for individualized stimulation montages to leverage the method to its fullest potential.",
author = "{von Conta}, Jill and Kasten, {Florian H} and Branislava {\'C}ur{\v c}i{\'c}-Blake and Andr{\'e} Aleman and Axel Thielscher and Herrmann, {Christoph S}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = oct,
day = "13",
doi = "10.1038/s41598-021-99749-0",
language = "English",
volume = "11",
pages = "1--12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS)

AU - von Conta, Jill

AU - Kasten, Florian H

AU - Ćurčić-Blake, Branislava

AU - Aleman, André

AU - Thielscher, Axel

AU - Herrmann, Christoph S

N1 - © 2021. The Author(s).

PY - 2021/10/13

Y1 - 2021/10/13

N2 - Transcranial temporal interference stimulation (tTIS) is a novel non-invasive brain stimulation technique for electrical stimulation of neurons at depth. Deep brain regions are generally small in size, making precise targeting a necessity. The variability of electric fields across individual subjects resulting from the same tTIS montages is unknown so far and may be of major concern for precise tTIS targeting. Therefore, the aim of the current study is to investigate the variability of the electric fields due to tTIS across 25 subjects. To this end, the electric fields of different electrode montages consisting of two electrode pairs with different center frequencies were simulated in order to target selected regions-of-interest (ROIs) with tTIS. Moreover, we set out to compare the electric fields of tTIS with the electric fields of conventional tACS. The latter were also based on two electrode pairs, which, however, were driven in phase at a common frequency. Our results showed that the electric field strengths inside the ROIs (left hippocampus, left motor area and thalamus) during tTIS are variable on single subject level. In addition, tTIS stimulates more focally as compared to tACS with much weaker co-stimulation of cortical areas close to the stimulation electrodes. Electric fields inside the ROI were, however, comparable for both methods. Overall, our results emphasize the potential benefits of tTIS for the stimulation of deep targets, over conventional tACS. However, they also indicate a need for individualized stimulation montages to leverage the method to its fullest potential.

AB - Transcranial temporal interference stimulation (tTIS) is a novel non-invasive brain stimulation technique for electrical stimulation of neurons at depth. Deep brain regions are generally small in size, making precise targeting a necessity. The variability of electric fields across individual subjects resulting from the same tTIS montages is unknown so far and may be of major concern for precise tTIS targeting. Therefore, the aim of the current study is to investigate the variability of the electric fields due to tTIS across 25 subjects. To this end, the electric fields of different electrode montages consisting of two electrode pairs with different center frequencies were simulated in order to target selected regions-of-interest (ROIs) with tTIS. Moreover, we set out to compare the electric fields of tTIS with the electric fields of conventional tACS. The latter were also based on two electrode pairs, which, however, were driven in phase at a common frequency. Our results showed that the electric field strengths inside the ROIs (left hippocampus, left motor area and thalamus) during tTIS are variable on single subject level. In addition, tTIS stimulates more focally as compared to tACS with much weaker co-stimulation of cortical areas close to the stimulation electrodes. Electric fields inside the ROI were, however, comparable for both methods. Overall, our results emphasize the potential benefits of tTIS for the stimulation of deep targets, over conventional tACS. However, they also indicate a need for individualized stimulation montages to leverage the method to its fullest potential.

UR - http://www.scopus.com/inward/record.url?scp=85117379980&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-99749-0

DO - 10.1038/s41598-021-99749-0

M3 - Journal article

C2 - 34645895

VL - 11

SP - 1

EP - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 20357

ER -

ID: 68353449