TY - JOUR
T1 - Interfractional Dose Accumulation for MR-guided Liver SBRT
T2 - Variation Among Algorithms is Highly Patient- and Fraction-dependent
AU - Wahlstedt, Isak
AU - George Smith, Abraham
AU - Andersen, Claus E
AU - Behrens, Claus P
AU - Nørring Bekke, Susanne
AU - Boye, Kristian
AU - van Overeem Felter, Mette
AU - Josipovic, Mirjana
AU - Petersen, Jens
AU - Lenora Risumlund, Signe
AU - Tascón-Vidarte, José D
AU - van Timmeren, Janita E
AU - Vogelius, Ivan R
N1 - Copyright © 2022. Published by Elsevier B.V.
PY - 2023/5
Y1 - 2023/5
N2 - BACKGROUND AND PURPOSE: Daily plan adaptations could take the dose delivered in previous fractions into account. Due to high dose delivered per fraction, low number of fractions, steep dose gradients, and large interfractional organ deformations, this might be particularly important for liver SBRT. This study investigates inter-algorithm variation of interfractional dose accumulation for MR-guided liver SBRT.MATERIALS AND METHODS: We assessed 27 consecutive MR-guided liver SBRT treatments of 67.5 Gy in three (n=15) or 50 Gy in five fractions (n=12), both prescribed to the GTV. We calculated fraction doses on daily patient anatomy, warped these doses to the simulation MRI using seven different algorithms, and accumulated the warped doses. Thus, we obtained differences in planned doses and warped or accumulated doses for each algorithm. This enabled us to calculate the inter-algorithm variations in warped doses per fraction and in accumulated doses per treatment course.RESULTS: The four intensity-based algorithms were more consistent with planned PTV dose than affine or contour-based algorithms. The mean (range) variation of the dose difference for PTV D95% due to dose warping by these intensity-based algorithms was 10.4 percentage points (0.3 to 43.7) between fractions and 8.6 (0.3 to 24.9) between accumulated treatment doses. As seen by these ranges, the variation was very dependent on the patient and the fraction being analyzed. Nevertheless, no correlations between patient or plan characteristics on the one hand and inter-algorithm dose warping variation on the other hand was found.CONCLUSION: Inter-algorithm dose accumulation variation is highly patient- and fraction-dependent for MR-guided liver SBRT. We advise against trusting a single algorithm for dose accumulation in liver SBRT.
AB - BACKGROUND AND PURPOSE: Daily plan adaptations could take the dose delivered in previous fractions into account. Due to high dose delivered per fraction, low number of fractions, steep dose gradients, and large interfractional organ deformations, this might be particularly important for liver SBRT. This study investigates inter-algorithm variation of interfractional dose accumulation for MR-guided liver SBRT.MATERIALS AND METHODS: We assessed 27 consecutive MR-guided liver SBRT treatments of 67.5 Gy in three (n=15) or 50 Gy in five fractions (n=12), both prescribed to the GTV. We calculated fraction doses on daily patient anatomy, warped these doses to the simulation MRI using seven different algorithms, and accumulated the warped doses. Thus, we obtained differences in planned doses and warped or accumulated doses for each algorithm. This enabled us to calculate the inter-algorithm variations in warped doses per fraction and in accumulated doses per treatment course.RESULTS: The four intensity-based algorithms were more consistent with planned PTV dose than affine or contour-based algorithms. The mean (range) variation of the dose difference for PTV D95% due to dose warping by these intensity-based algorithms was 10.4 percentage points (0.3 to 43.7) between fractions and 8.6 (0.3 to 24.9) between accumulated treatment doses. As seen by these ranges, the variation was very dependent on the patient and the fraction being analyzed. Nevertheless, no correlations between patient or plan characteristics on the one hand and inter-algorithm dose warping variation on the other hand was found.CONCLUSION: Inter-algorithm dose accumulation variation is highly patient- and fraction-dependent for MR-guided liver SBRT. We advise against trusting a single algorithm for dose accumulation in liver SBRT.
KW - Algorithms
KW - Humans
KW - Liver/diagnostic imaging
KW - Radiosurgery
KW - Radiotherapy Dosage
KW - Radiotherapy Planning, Computer-Assisted
KW - Radiotherapy, Intensity-Modulated
KW - Liver metastases
KW - MR-guided radiotherapy
KW - Radiotherapy
KW - Deformable image registration
KW - Dose accumulation
KW - SABR
UR - http://www.scopus.com/inward/record.url?scp=85149621034&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2022.109448
DO - 10.1016/j.radonc.2022.109448
M3 - Journal article
C2 - 36566988
SN - 0167-8140
VL - 182
JO - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
M1 - 109448
ER -