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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis

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  1. Managing patients on direct factor Xa inhibitors with rapid thrombelastography

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  2. Denosumab vs. zoledronic acid treatment in post-menopausal breast cancer: a 2-year prospective observational study

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  3. Plasma glycerol levels in men with hypertriglyceridemia

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  4. Quantification of biotin in plasma samples by column switching liquid chromatography - tandem mass spectrometry

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  5. Reference intervals for 12 clinical laboratory tests in a Danish population: The Lolland-Falster Health Study

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  1. Increase of Ki-67 index and influence on mortality in patients with neuroendocrine neoplasms

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  2. A short report of 50 patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN)

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  3. Neuroendocrine neoplasms of the appendix: Characterization of 335 patients referred to the Copenhagen NET Center of Excellence

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We describe a 34-year-old female treated with IFN-β for 8 years with a biochemical profile suggestive of acromegaly. The patient presented with elevated serum insulin-like growth factor-I (IGF-I) and insufficient suppression of growth hormone (GH) during oral glucose tolerance test (OGTT). There were no clinical features of acromegaly. A 5-day profile showed higher GH levels on the 3 days following IFN-β injections. Total and bioactive IGF-I were also elevated but did not fluctuate. Four weeks off IFN-β normalized suppression of GH during OGTT but did not reduce serum IGF-I or bioactive IGF-I. In conclusion, IFN-β treatment mimicked acromegaly biochemically. The changes were partially reversible.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume70
Issue number7
Pages (from-to)519-22
Number of pages4
ISSN0036-5513
DOIs
Publication statusPublished - 2010

    Research areas

  • Acromegaly, Administration, Oral, Adult, Estradiol, Female, Glucose, Glucose Tolerance Test, Growth Hormone, Humans, Hydrocortisone, Interferon-beta, Multiple Sclerosis, Pituitary Hormones, Thyroid Hormones

ID: 34760478