Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production

Chris J Hedegaard; Finn Sellebjerg; Martin Krakauer; Dan Hesse; Klaus Bendtzen; Claus H Nielsen

doi:10.1177/1352458510393771

Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production

Chris J Hedegaard, Finn Sellebjerg, Martin Krakauer, Dan Hesse, Klaus Bendtzen, Claus H Nielsen

Department of Neurology

22 Citations (Scopus)

Abstract

Treatment with interferon-beta (IFN-beta) increases B-cell activating factor of the TNF family (BAFF) expression in multiple sclerosis (MS), raising the concern that treatment of MS patients with IFN-beta may activate autoimmune B cells and stimulate the production of MS-associated autoantibodies.

Original language	English
Journal	Multiple Sclerosis
Volume	17
Issue number	5
Pages (from-to)	567-77
Number of pages	11
ISSN	1352-4585
DOIs	https://doi.org/10.1177/1352458510393771
Publication status	Published - 1 May 2011

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title = "Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production",

abstract = "Treatment with interferon-beta (IFN-beta) increases B-cell activating factor of the TNF family (BAFF) expression in multiple sclerosis (MS), raising the concern that treatment of MS patients with IFN-beta may activate autoimmune B cells and stimulate the production of MS-associated autoantibodies.",

author = "Hedegaard, {Chris J} and Finn Sellebjerg and Martin Krakauer and Dan Hesse and Klaus Bendtzen and Nielsen, {Claus H}",

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AU - Hedegaard, Chris J

AU - Sellebjerg, Finn

AU - Krakauer, Martin

AU - Hesse, Dan

AU - Bendtzen, Klaus

AU - Nielsen, Claus H

PY - 2011/5/1

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N2 - Treatment with interferon-beta (IFN-beta) increases B-cell activating factor of the TNF family (BAFF) expression in multiple sclerosis (MS), raising the concern that treatment of MS patients with IFN-beta may activate autoimmune B cells and stimulate the production of MS-associated autoantibodies.

AB - Treatment with interferon-beta (IFN-beta) increases B-cell activating factor of the TNF family (BAFF) expression in multiple sclerosis (MS), raising the concern that treatment of MS patients with IFN-beta may activate autoimmune B cells and stimulate the production of MS-associated autoantibodies.

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DO - 10.1177/1352458510393771

M3 - Journal article

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VL - 17

SP - 567

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JO - Multiple Sclerosis

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Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production

Abstract

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