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The Capital Region of Denmark
- a part of Copenhagen University Hospital
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Interaction between VEGF and calcium-independent phospholipase A2 in proliferation and migration of retinal pigment epithelium
Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of VEGF in the eye is an important treatment modality for reducing proliferation and migration of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD). Additionally, previous studies suggest calcium-independent phospholipase A(2) group VIA (iPLA(2)-VIA) to be a potential regulator of cell proliferation and migration, and evidence show abundant expression of iPLA(2)-VIA in RPE cells. The aim of the present study was to evaluate the potential role of iPLA(2)-VIA in VEGF-induced proliferation and migration of RPE cells.
| Original language | English |
|---|---|
| Journal | Current Eye Research |
| Volume | 37 |
| Issue number | 6 |
| Pages (from-to) | 500-7 |
| Number of pages | 8 |
| ISSN | 0271-3683 |
| DOIs | |
| Publication status | Published - 2012 |
- Blotting, Western, Cell Line, Cell Movement, Cell Proliferation, DNA Replication, Group VI Phospholipases A2, Humans, Naphthalenes, Phosphodiesterase Inhibitors, Pyrones, Retinal Pigment Epithelium, Transcriptional Activation, Up-Regulation, Vascular Endothelial Growth Factor A
Research areas
ID: 36611684