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Interaction between VEGF and calcium-independent phospholipase A2 in proliferation and migration of retinal pigment epithelium

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  5. Clinical and molecular markers in retinal detachment-From hyperreflective points to stem cells and inflammation

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  • Anne Katrine Kehler
  • Emelie Cammilla Andersen
  • Jens Rovelt Andreasen
  • Rupali Vohra
  • Nanna Junker
  • Kristian Arild Poulsen
  • Miriam Kolko
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Inhibition of VEGF in the eye is an important treatment modality for reducing proliferation and migration of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD). Additionally, previous studies suggest calcium-independent phospholipase A(2) group VIA (iPLA(2)-VIA) to be a potential regulator of cell proliferation and migration, and evidence show abundant expression of iPLA(2)-VIA in RPE cells. The aim of the present study was to evaluate the potential role of iPLA(2)-VIA in VEGF-induced proliferation and migration of RPE cells.
Original languageEnglish
JournalCurrent Eye Research
Volume37
Issue number6
Pages (from-to)500-7
Number of pages8
ISSN0271-3683
DOIs
Publication statusPublished - 2012

    Research areas

  • Blotting, Western, Cell Line, Cell Movement, Cell Proliferation, DNA Replication, Group VI Phospholipases A2, Humans, Naphthalenes, Phosphodiesterase Inhibitors, Pyrones, Retinal Pigment Epithelium, Transcriptional Activation, Up-Regulation, Vascular Endothelial Growth Factor A

ID: 36611684