Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen, Ulla Vogel, Jane Christensen, Rikke D Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Tolstrup

25 Citations (Scopus)

Abstract

Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

Original languageEnglish
JournalCancer Letters
Volume295
Issue number2
Pages (from-to)191-7
Number of pages7
ISSN0304-3835
DOIs
Publication statusPublished - 28 Sept 2010

Keywords

  • Alcohol Dehydrogenase/genetics
  • Alcohol Drinking/adverse effects
  • Breast Neoplasms/etiology
  • Ethanol/adverse effects
  • Female
  • Humans
  • Middle Aged
  • Polymorphism, Genetic
  • Risk Factors

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