Intensive blood pressure control affects cerebral blood flow in type 2 diabetes mellitus patients

Yu-Sok Kim; Shyrin C A T Davis; Jasper Truijen; Wim J Stok; Niels H Secher; Johannes J van Lieshout

doi:10.1161/HYPERTENSIONAHA.110.160523

Intensive blood pressure control affects cerebral blood flow in type 2 diabetes mellitus patients

Yu-Sok Kim, Shyrin C A T Davis, Jasper Truijen, Wim J Stok, Niels H Secher, Johannes J van Lieshout

43 Citations (Scopus)

Abstract

Type 2 diabetes mellitus is associated with microvascular complications, hypertension, and impaired dynamic cerebral autoregulation. Intensive blood pressure (BP) control in hypertensive type 2 diabetic patients reduces their risk of stroke but may affect cerebral perfusion. Systemic hemodynamic variables and transcranial Doppler-determined cerebral blood flow velocity (CBFV), cerebral CO(2) responsiveness, and cognitive function were determined after 3 and 6 months of intensive BP control in 17 type 2 diabetic patients with microvascular complications (T2DM+), in 18 diabetic patients without (T2DM-) microvascular complications, and in 16 nondiabetic hypertensive patients. Cerebrovascular reserve capacity was lower in T2DM+ versus T2DM- and nondiabetic hypertensive patients (4.6±1.1 versus 6.0±1.6 [P

Original language	English
Journal	Hypertension
Volume	57
Issue number	4
Pages (from-to)	738-45
Number of pages	8
ISSN	0194-911X
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.110.160523
Publication status	Published - 1 Apr 2011

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title = "Intensive blood pressure control affects cerebral blood flow in type 2 diabetes mellitus patients",

abstract = "Type 2 diabetes mellitus is associated with microvascular complications, hypertension, and impaired dynamic cerebral autoregulation. Intensive blood pressure (BP) control in hypertensive type 2 diabetic patients reduces their risk of stroke but may affect cerebral perfusion. Systemic hemodynamic variables and transcranial Doppler-determined cerebral blood flow velocity (CBFV), cerebral CO(2) responsiveness, and cognitive function were determined after 3 and 6 months of intensive BP control in 17 type 2 diabetic patients with microvascular complications (T2DM+), in 18 diabetic patients without (T2DM-) microvascular complications, and in 16 nondiabetic hypertensive patients. Cerebrovascular reserve capacity was lower in T2DM+ versus T2DM- and nondiabetic hypertensive patients (4.6±1.1 versus 6.0±1.6 [P",

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AU - Kim, Yu-Sok

AU - Davis, Shyrin C A T

AU - Truijen, Jasper

AU - Stok, Wim J

AU - Secher, Niels H

AU - van Lieshout, Johannes J

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N2 - Type 2 diabetes mellitus is associated with microvascular complications, hypertension, and impaired dynamic cerebral autoregulation. Intensive blood pressure (BP) control in hypertensive type 2 diabetic patients reduces their risk of stroke but may affect cerebral perfusion. Systemic hemodynamic variables and transcranial Doppler-determined cerebral blood flow velocity (CBFV), cerebral CO(2) responsiveness, and cognitive function were determined after 3 and 6 months of intensive BP control in 17 type 2 diabetic patients with microvascular complications (T2DM+), in 18 diabetic patients without (T2DM-) microvascular complications, and in 16 nondiabetic hypertensive patients. Cerebrovascular reserve capacity was lower in T2DM+ versus T2DM- and nondiabetic hypertensive patients (4.6±1.1 versus 6.0±1.6 [P

AB - Type 2 diabetes mellitus is associated with microvascular complications, hypertension, and impaired dynamic cerebral autoregulation. Intensive blood pressure (BP) control in hypertensive type 2 diabetic patients reduces their risk of stroke but may affect cerebral perfusion. Systemic hemodynamic variables and transcranial Doppler-determined cerebral blood flow velocity (CBFV), cerebral CO(2) responsiveness, and cognitive function were determined after 3 and 6 months of intensive BP control in 17 type 2 diabetic patients with microvascular complications (T2DM+), in 18 diabetic patients without (T2DM-) microvascular complications, and in 16 nondiabetic hypertensive patients. Cerebrovascular reserve capacity was lower in T2DM+ versus T2DM- and nondiabetic hypertensive patients (4.6±1.1 versus 6.0±1.6 [P

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DO - 10.1161/HYPERTENSIONAHA.110.160523

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Intensive blood pressure control affects cerebral blood flow in type 2 diabetes mellitus patients

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