Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Combined burden and functional impact tests for cancer driver discovery using DriverPower

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Association between Mental Disorders and Subsequent Medical Conditions

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Von Frey testing revisited - provision of an online algorithm for improved accuracy of 50% thresholds

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The donors perceived positive and negative effects of blood donation

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Familial analysis reveals rare risk variants for migraine in regulatory regions

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

Original languageEnglish
JournalNature Communications
Volume10
Issue number1
Pages (from-to)2548
ISSN2041-1723
DOIs
Publication statusPublished - 11 Jun 2019

    Research areas

  • Cohort Studies, DNA/blood, DNA Methylation/genetics, Epigenesis, Genetic, Female, Fetal Blood, Gene-Environment Interaction, Genotype, Humans, Infant, Newborn, Male, Pregnancy, Risk Factors

ID: 59084457