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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Insulin-like growth factor 1 and growth hormone in chronic liver disease.

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Somatomedins or insulin-like growth factors (IGF) are peptides synthesized in the liver. IGFs have different anabolic and metabolic actions and are important in normal growth and development. The concentration of insulin-like growth factor 1 (IGF-1) is low in patients with chronic liver disease mainly due to the decreased liver function. Low levels of somatomedins are also seen in patients with growth hormone (GH) insufficiency, renal impairment, and malnutrition. GH stimulates the production of IGF-1, and both are part of a negative feedback system acting on hepatic, pituitary, and hypothalamic levels. The basal and stimulated GH concentration is pathologically elevated in patients with chronic liver disease and may be due to a disturbed regulation. Alterations in liver IGF receptors in patients with chronic liver disease still require investigation as they may be important for the liver function.
Translated title of the contributionInsulin-like growth factor 1 and growth hormone in chronic liver disease.
Original languageEnglish
JournalDigestive Diseases
Volume10
Issue number4
Pages (from-to)239-248
Number of pages10
ISSN0257-2753
Publication statusPublished - 1992

ID: 32542761