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Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

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Wolthers, Benjamin Ole ; Mogensen, Pernille R ; Frandsen, Thomas L ; Abrahamsson, Jonas ; Behrendtz, Mikael ; Heyman, Mats ; Lohi, Olli ; Norén-Nyström, Ulrika ; Ruud, Ellen ; Schmiegelow, Kjeld. / Insulin-dependent diabetes : A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. In: Pediatric Blood & Cancer. 2019 ; Vol. 66, No. 1. pp. e27437.

Bibtex

@article{e69a48b4437a44d499cd34338cf58d17,
title = "Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia",
abstract = "Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7-9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.",
keywords = "acute lymphoblastic leukemia, diabetes, pancreatitis, toxicity",
author = "Wolthers, {Benjamin Ole} and Mogensen, {Pernille R} and Frandsen, {Thomas L} and Jonas Abrahamsson and Mikael Behrendtz and Mats Heyman and Olli Lohi and Ulrika Nor{\'e}n-Nystr{\"o}m and Ellen Ruud and Kjeld Schmiegelow",
note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2019",
month = jan,
day = "1",
doi = "10.1002/pbc.27437",
language = "English",
volume = "66",
pages = "e27437",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Insulin-dependent diabetes

T2 - A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

AU - Wolthers, Benjamin Ole

AU - Mogensen, Pernille R

AU - Frandsen, Thomas L

AU - Abrahamsson, Jonas

AU - Behrendtz, Mikael

AU - Heyman, Mats

AU - Lohi, Olli

AU - Norén-Nyström, Ulrika

AU - Ruud, Ellen

AU - Schmiegelow, Kjeld

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7-9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

AB - Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7-9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

KW - acute lymphoblastic leukemia

KW - diabetes

KW - pancreatitis

KW - toxicity

U2 - 10.1002/pbc.27437

DO - 10.1002/pbc.27437

M3 - Journal article

C2 - 30216644

VL - 66

SP - e27437

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 1

ER -

ID: 55741629