Insulin resistance is associated with multiple chemical sensitivity in a danish population-based study—DanFunD

Anne A. Bjerregaard*, Marie W. Petersen, Lise Kirstine Gormsen, Sine Skovbjerg, Niklas R. Jørgensen, Allan Linneberg, José G. Cedeño-Laurent, Torben Jørgensen, Thomas M. Dantoft

*Corresponding author for this work
3 Citations (Scopus)


Multiple chemical sensitivity (MCS) is a multisystem syndrome, and limited knowledge of its pathophysiology exists. Based on the population-based Danish cohort DanFunD, this study investigated metabolic health in people with MCS compared to individuals who did not have MCS. From 9656 cohort participants aged 18–76 years old, 1.95% were categorized as MCS individuals with comorbid functional somatic disorders (MCS + FSD, n = 188), and 1.13% were categorized as MCS without functional somatic disorders (MCS ÷ FSD, n = 109). MCS was characterized based on three criteria: the experience of symptoms upon exposure to common odors and airborne chemicals, symptoms related the central nervous systems and others organ symptoms, and significant impact on every day, social, and occupational life. The remaining study population without MCS or any other functional somatic disorders were regarded as controls. We used adjusted multiple linear regression with link-function to evaluate the associations between lipid and glucose metabolism markers and MCS. We also tested the odds ratio of metabolic syndrome in MCS. Results did not point to statistically significant associations between lipid biomarkers or metabolic syndrome and both MCS groups compared to the controls. We found that MCS individuals may be more insulin resistant and that MCS ÷ FSD may have an impaired glucose metabolism when compared to controls.

Original languageEnglish
Article number12654
JournalInternational Journal of Environmental Research and Public Health
Issue number23
Publication statusPublished - 30 Nov 2021


  • Adolescent
  • Adult
  • Aged
  • Cohort Studies
  • Denmark/epidemiology
  • Humans
  • Insulin Resistance
  • Middle Aged
  • Multiple Chemical Sensitivity/epidemiology
  • Odds Ratio
  • Young Adult


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