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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency

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Background: As people living with HIV (PLWH) are growing older, there is increased incidence of metabolic diseases, including type 2 diabetes mellitus, for which insulin resistance is a key determinant. In this study, we aimed to investigate risk factors associated with insulin resistance in PLWH. Methods: We included well-treated PLWH without hepatitis co-infection, and with available fasting serum insulin and plasma glucose (n = 643) from the Copenhagen Comorbidity in HIV Infection Study. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). We investigated the association between risk factors and high HOMA-IR in a logistic regression model adjusted for age, sex, abdominal obesity, smoking status, and origin. When including use of thymidine analogues and/or didanosine in the model, we also adjusted for time with HIV. Results: Median (IQR) age of PLWH was 52 years (46–61), and 87% (n = 557) were male. Median (IQR) HOMA-IR was 1.86 (1.23–3.14) mmol/L × mU/L. Risk factors significantly associated with high HOMA-IR included older age, BMI ≥ 25, abdominal obesity, waist circumference, use of thymidine analogues and/or didanosine, time with HIV, and CD4 + nadir < 200 cells/µL. Conclusions: Insulin resistance in PLWH is associated with both use of thymidine analogues and/or didanosine and prior immunodeficiency suggesting that increased attention on blood glucose in these patients could be beneficial.

Original languageEnglish
Article number503
JournalBMC Infectious Diseases
Volume22
Issue number1
Pages (from-to)1-6
Number of pages6
ISSN1471-2334
DOIs
Publication statusPublished - 28 May 2022

Bibliographical note

© 2022. The Author(s).

    Research areas

  • Diabetes Mellitus, Type 2/complications, Didanosine/adverse effects, Female, HIV Infections/complications, Humans, Insulin Resistance, Male, Middle Aged, Obesity/epidemiology, Obesity, Abdominal/complications, Thymidine, Comorbidity, HIV-infection, Antiretroviral therapy, Insulin resistance, Diabetes

ID: 78453244