Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer

Adam Vilmar; Eric Santoni-Rugiu; Jesus Garcia-Fon Cillas; Marsisol Huarriz; Jens Benn Sørensen

Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer

Adam Vilmar, Eric Santoni-Rugiu, Jesus Garcia-Fon Cillas, Marsisol Huarriz, Jens Benn Sørensen

Department of Pathology

14 Citations (Scopus)

Abstract

BACKGROUND: The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).

MATERIALS AND METHODS: Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.

RESULTS: Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.

CONCLUSION: IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.

Original language	English
Journal	Anticancer Research
Volume	34
Issue number	6
Pages (from-to)	2991-6
Number of pages	6
ISSN	0250-7005
Publication status	Published - Jun 2014

Keywords

Adenocarcinoma
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Large Cell
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Cohort Studies
Female
Follow-Up Studies
Humans
Immunoenzyme Techniques
Lung Neoplasms
Male
Middle Aged
Neoplasm Staging
Prognosis
RNA, Messenger
Real-Time Polymerase Chain Reaction
Receptor, IGF Type 1
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Tumor Markers, Biological
Young Adult

Cite this

@article{c983d91ee7104730b54c64def8ac34e2,

title = "Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer",

abstract = "BACKGROUND: The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).MATERIALS AND METHODS: Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.RESULTS: Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.CONCLUSION: IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.",

keywords = "Adenocarcinoma, Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Large Cell, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Cohort Studies, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Prognosis, RNA, Messenger, Real-Time Polymerase Chain Reaction, Receptor, IGF Type 1, Reverse Transcriptase Polymerase Chain Reaction, Survival Rate, Tumor Markers, Biological, Young Adult",

author = "Adam Vilmar and Eric Santoni-Rugiu and Cillas, \{Jesus Garcia-Fon\} and Marsisol Huarriz and S{\o}rensen, \{Jens Benn\}",

year = "2014",

month = jun,

language = "English",

volume = "34",

pages = "2991--6",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6",

}

TY - JOUR

T1 - Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer

AU - Vilmar, Adam

AU - Santoni-Rugiu, Eric

AU - Cillas, Jesus Garcia-Fon

AU - Huarriz, Marsisol

AU - Sørensen, Jens Benn

PY - 2014/6

Y1 - 2014/6

N2 - BACKGROUND: The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).MATERIALS AND METHODS: Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.RESULTS: Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.CONCLUSION: IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.

AB - BACKGROUND: The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).MATERIALS AND METHODS: Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.RESULTS: Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.CONCLUSION: IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.

KW - Adenocarcinoma

KW - Adolescent

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Carcinoma, Large Cell

KW - Carcinoma, Non-Small-Cell Lung

KW - Carcinoma, Squamous Cell

KW - Cohort Studies

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunoenzyme Techniques

KW - Lung Neoplasms

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Prognosis

KW - RNA, Messenger

KW - Real-Time Polymerase Chain Reaction

KW - Receptor, IGF Type 1

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Survival Rate

KW - Tumor Markers, Biological

KW - Young Adult

UR - https://www.scopus.com/pages/publications/84906313304

M3 - Journal article

C2 - 24922664

SN - 0250-7005

VL - 34

SP - 2991

EP - 2996

JO - Anticancer Research

JF - Anticancer Research

IS - 6

ER -

Insulin-like growth factor receptor 1 mRNA expression as a prognostic marker in advanced non-small cell lung cancer

Abstract

Keywords

Other files and links

Fingerprint

Cite this