Abstract
OBJECTIVE: To examine vaginal insulin-like growth factor binding protein 1 (IGFBP-1) as a marker of preterm delivery, amniotic fluid leakage or vaginal infection.
MATERIALS AND METHODS: The material consisted of a nested case-control study (67 with idiopathic preterm delivery and 406 randomly selected women with term deliveries) from a prospective cohort of 2,846 women.
RESULTS: Vaginal npIGFBP-1 was weakly associated with preterm delivery. Elevated npIGFBP-1 gave an increased risk of preterm delivery (OR 2.8 [1.4-6. 7]). Elevated IGFBP-1 provided a sensitivity of 13% at a false-positive rate of 4.4% in a low-risk population. When adjusting for other covariates associated with preterm delivery the association between npIGFBP-1 and preterm delivery disappeared; there was an interaction between alcohol consumption and npIGFBP-1.
CONCLUSION: The current study found vaginal npIGFBP-1 to be weakly associated with gestational age at delivery. However, in this study the association may potentially be explained by alcohol consumption.
| Original language | English |
|---|---|
| Journal | In vivo (Athens, Greece) |
| Volume | 18 |
| Issue number | 1 |
| Pages (from-to) | 37-41 |
| Number of pages | 5 |
| ISSN | 0258-851X |
| Publication status | Published - 12 Mar 2004 |
| Externally published | Yes |
Keywords
- Amniotic Fluid
- Case-Control Studies
- Female
- Fetal Membranes, Premature Rupture
- Gestational Age
- Humans
- Insulin-Like Growth Factor Binding Protein 1
- Obstetric Labor, Premature
- Phosphorylation
- Pregnancy
- Pregnancy Complications, Infectious
- Pregnancy Proteins
- Proportional Hazards Models
- Prospective Studies
- Vagina
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, P.H.S.
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