TY - JOUR
T1 - Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
AU - Orrù, Stefania
AU - Imperlini, Esther
AU - Vitucci, Daniela
AU - Caterino, Marianna
AU - Mandola, Annalisa
AU - Randers, Morten Bredsgaard
AU - Schmidt, Jakob Friis
AU - Hagman, Marie
AU - Andersen, Thomas Rostgaard
AU - Krustrup, Peter
AU - Ruoppolo, Margherita
AU - Buono, Pasqualina
AU - Mancini, Annamaria
PY - 2022/11/28
Y1 - 2022/11/28
N2 - BACKGROUND: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.METHODS: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools.RESULTS: Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.CONCLUSIONS: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.
AB - BACKGROUND: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.METHODS: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools.RESULTS: Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.CONCLUSIONS: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.
KW - Aged
KW - Humans
KW - Quality of Life
KW - Proteomics
KW - Muscle, Skeletal/physiology
KW - Football
KW - Soccer
UR - http://www.scopus.com/inward/record.url?scp=85143736122&partnerID=8YFLogxK
U2 - 10.3390/ijerph192315835
DO - 10.3390/ijerph192315835
M3 - Journal article
C2 - 36497910
VL - 19
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 23
M1 - 15835
ER -