Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes

Jørgen Rungby

doi:10.1517/13543780902953707

Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes

Jørgen Rungby

Department of Endocrinology

6 Citations (Scopus)

Abstract

BI 1356, a xanthine-based DPP-4 inhibitor, has reached Phase III trials. The compound efficiently inhibits dipeptidyl peptidase 4 (DPP-4) in vitro and in vivo. In vivo GLP-1 levels increase to levels at or above the levels of other DPP-4 inhibitors. Preclinical trials suggest a once-daily administration of 5 mg to be efficient, long-lasting and without known side effects.

Original language	English
Journal	Expert Opinion on Investigational Drugs
Volume	18
Issue number	6
Pages (from-to)	835-838
Number of pages	4
ISSN	1354-3784
DOIs	https://doi.org/10.1517/13543780902953707
Publication status	Published - 2009

Keywords

Animals
Antigens, CD26
Clinical Trials as Topic
Diabetes Mellitus, Type 2
Drugs, Investigational
Glucagon-Like Peptide 1
Humans
Insulin-Secreting Cells
Molecular Structure
Purines
Quinazolines

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abstract = "BI 1356, a xanthine-based DPP-4 inhibitor, has reached Phase III trials. The compound efficiently inhibits dipeptidyl peptidase 4 (DPP-4) in vitro and in vivo. In vivo GLP-1 levels increase to levels at or above the levels of other DPP-4 inhibitors. Preclinical trials suggest a once-daily administration of 5 mg to be efficient, long-lasting and without known side effects.",

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N2 - BI 1356, a xanthine-based DPP-4 inhibitor, has reached Phase III trials. The compound efficiently inhibits dipeptidyl peptidase 4 (DPP-4) in vitro and in vivo. In vivo GLP-1 levels increase to levels at or above the levels of other DPP-4 inhibitors. Preclinical trials suggest a once-daily administration of 5 mg to be efficient, long-lasting and without known side effects.

AB - BI 1356, a xanthine-based DPP-4 inhibitor, has reached Phase III trials. The compound efficiently inhibits dipeptidyl peptidase 4 (DPP-4) in vitro and in vivo. In vivo GLP-1 levels increase to levels at or above the levels of other DPP-4 inhibitors. Preclinical trials suggest a once-daily administration of 5 mg to be efficient, long-lasting and without known side effects.

KW - Animals

KW - Antigens, CD26

KW - Clinical Trials as Topic

KW - Diabetes Mellitus, Type 2

KW - Drugs, Investigational

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Insulin-Secreting Cells

KW - Molecular Structure

KW - Purines

KW - Quinazolines

UR - https://www.scopus.com/pages/publications/67649600688

U2 - 10.1517/13543780902953707

DO - 10.1517/13543780902953707

M3 - Journal article

SN - 1354-3784

VL - 18

SP - 835

EP - 838

JO - Expert Opinion on Investigational Drugs

JF - Expert Opinion on Investigational Drugs

IS - 6

ER -

Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes

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