Inhibin B in the assessment of seminiferous tubular function

45 Citations (Scopus)


Inhibin B is a testicular hormone that regulates follicle-stimulating hormone secretion in a negative feedback loop. In males, the serum level of inhibin B is detectable throughout life, with a prominent change in the first year of life and during puberty, reflecting the testicular response to the activity of the hypothalamic-pituitary-gonadal hormone axis. During childhood, the basal serum inhibin B level is a direct marker of the presence and function of testicular tissue that has proved useful in the diagnosis of patients with cryptorchidism or ambiguous genitalia. In adult men, the inhibin B level is closely related to spermatogenesis. Measurements of serum inhibin B may provide valuable clues for the differential diagnosis of male infertility. A further exploration of the relationship between inhibin B, Sertoli cell function and spermatogenesis will improve the usefulness of inhibin B as a tool in the investigation of male reproductive health.
Original languageEnglish
JournalBest Practice & Research: Clinical Endocrinology & Metabolism
Issue number3
Pages (from-to)389-97
Number of pages9
Publication statusPublished - Sept 2000


  • Aging
  • Animals
  • Humans
  • Inhibins
  • Male
  • Prostatic Secretory Proteins
  • Seminiferous Tubules
  • Structure-Activity Relationship


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