Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Randomized Controlled Trial of Tesomet for Weight Loss in Hypothalamic Obesity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Dynamic human liver proteome atlas reveals functional insights into disease pathways

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effect of Meal Texture on Postprandial Glucose Excursions and Gut Hormones After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Effects and safety of natriuretic peptides as treatment of cirrhotic ascites: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been hypothesised to contribute to the development of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). It is unknown whether OXPHOS capacities in human visceral (VAT) and subcutaneous adipose tissue (SAT) associate with NAFLD severity and how hepatic OXPHOS responds to improvement in NAFLD. In biopsies sampled from 62 patients with obesity undergoing bariatric surgery and nine control subjects without obesity we demonstrate that OXPHOS is reduced in VAT and SAT while increased in the liver in patients with obesity when compared with control subjects without obesity, but this was independent of NAFLD severity. In repeat liver biopsy sampling in 21 patients with obesity 12 months after bariatric surgery we found increased hepatic OXPHOS capacity and mitochondrial DNA/nuclear DNA content compared with baseline. In this work we show that obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD severity, however, bariatric surgery increases hepatic OXPHOS and mitochondrial biogenesis.

Original languageEnglish
Article number2931
JournalNature Communications
Volume13
Issue number1
Pages (from-to)1-15
Number of pages15
ISSN2041-1723
DOIs
Publication statusPublished - 25 May 2022

Bibliographical note

© 2022. The Author(s).

    Research areas

  • Adipose Tissue/pathology, Bariatric Surgery, Humans, Liver/pathology, Non-alcoholic Fatty Liver Disease/pathology, Obesity, Morbid/complications, Obesity/complications, Organelle Biogenesis, Respiration

ID: 78263977