Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Influence of coronary territory on flow profiles of saphenous vein grafts

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Influence of Mitroflow bioprosthesis structural valve deterioration on cardiac morbidity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. In-vitro and in-vivo evaluation of a novel bioprosthetic pulmonary valve for use in congenital heart surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Higher arterial pressure during cardiopulmonary bypass may not reduce the risk of acute kidney injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Multimodal analgesia versus traditional opiate based analgesia after cardiac surgery, a randomized controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mineralocorticoid receptor antagonist improves cardiac structure in Type 2 Diabetes: Data from the MIRAD Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Distinct non-ischemic myocardial late gadolinium enhancement lesions in patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Fibroblast growth factor-23 is associated with imaging markers of diabetic cardiomyopathy and anti-diabetic therapeutics

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cardiac perfusion, structure, and function in type 2 diabetes mellitus with and without diabetic complications

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Sanaz Amin
  • Raphael S Werner
  • Per Lav Madsen
  • George Krasopoulos
  • David P Taggart
View graph of relations

BACKGROUND: Differing perfusion of the left and right ventricular coronary territory may influence flow-profiles of saphenous vein grafts (SVGs). We compared flow parameters, measured by transit-time flowmetry (TTFM), in left- and right-sided SVGs during coronary artery by-pass grafting (CABG).

METHODS: Routine TTFM measurements were obtained in 167 SVGs to the left territory (55%) and 134 SVGs to the right territory (total of 301 SVGs in 207 patients). The four standard TTFM parameters, [mean graft flow (MGF), pulsatility index (PI), percentage diastolic filling (%DF), and percentage backward flow (%BF)] were compared. Differences in flow parameters were also examined according to surgical technique (on- vs. off-pump).

RESULTS: No significant difference between coronary territories was found for MGF, PI and %BF. However, a higher %DF was noted in left-sided SVGs in the overall cohort as well as in the on-pump (both p < 0.001) and the off-pump cohorts (p = 0.07). Further, a significantly higher %BF was found in SVGs performed off-pump to the left territory (1.2 ± 2.5 vs. 2.3 ± 3.0, p = 0.023). In a multivariate regression analysis, anastomosing a SVG to the left territory was weakly associated with higher PI (OR = 0.36, p = 0.026) and strongly associated with higher %DF (OR = 5.1, p < 0.001). No significant association was found for MGF, PI, %DF or %BF in either the on-pump nor the off-pump cohorts.

CONCLUSIONS: Although statistically significant, the established differences in TTFM parameters between left- and right-sided vein grafts were small and unlikely to be of clinical relevance.

Original languageEnglish
JournalJournal of Cardiothoracic Surgery
Volume13
Issue number1
Pages (from-to)23
ISSN1749-8090
DOIs
Publication statusPublished - 20 Feb 2018

    Research areas

  • Aged, Anastomosis, Surgical, Aorta/surgery, Blood Flow Velocity, Blood Pressure, Cardiopulmonary Bypass, Coronary Artery Bypass, Female, Heart/physiology, Humans, Male, Middle Aged, Multivariate Analysis, Retrospective Studies, Rheology, Saphenous Vein/transplantation

ID: 56349386