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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Infliximab dependency in a national cohort of children with Crohn's disease

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AIM: The aim was to evaluate the pattern of responsiveness and to monitor side effects of episodic administration of infliximab in children with active Crohn's disease (CD) treated in Denmark from 1999 to 2003.

MATERIAL AND METHODS: The National Danish Crohn Colitis Database of infliximab was used to identify all Danish CD patients treated at pediatric departments with infliximab. The clinical outcome was assessed by pattern recognition of the disease course 30 days after the first infliximab infusion and 90 days after intended end of treatment.

RESULTS: During a 3 year period, infliximab was given to 24 CD patients (9 male/15 female) aged median 15.4 (range 9.8-18.6) years with a median disease duration of 26 (range 0.7-93) months and a median number of infusions of 6 (range 2-11). Five milligrams of infliximab per kilogram infusions were given intravenously. Immediate response was as follows: 8 (33%) patients achieved complete response (CR), 10 (42%) partial response (PR), and 6 (25%) no response (NR). Long-term response was as follows: 7 (29%) patients achieved prolonged response (PRO), defined as maintenance of CR or PR, 10 (42%) were infliximab dependent (ID), defined as relapse of symptoms requiring reinfusions of infliximab to regain CR or PR, and 6 (25%) had NR. Six (25%) patients needed surgery during or after treatment with infliximab. Side effects were seen in four (17%) patients. No serious events were noted.

CONCLUSION: Seventy-one percent of the children appeared to benefit (PRO or ID) from infliximab treatment with minor side effects when given episodically. Among these patients, two response patterns were recognized: PRO after ending infliximab treatment (29%) or dependency on reinfusions of infliximab (42%).

Original languageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume42
Issue number1
Pages (from-to)40-5
Number of pages6
ISSN0277-2116
Publication statusPublished - 2006

    Research areas

  • Adolescent, Antibodies, Monoclonal, Child, Cohort Studies, Crohn Disease, Female, Gastrointestinal Agents, Humans, Infliximab, Infusions, Intravenous, Male, Recurrence, Remission Induction, Retrospective Studies, Time Factors, Treatment Outcome, Journal Article

ID: 32544919