Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Inflammatory response, fluid balance and outcome in emergency high-risk abdominal surgery

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Investigating the use of physical restraint of children in emergency departments: A Scandinavian survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The effects of adding quinolones to beta-lactam antibiotics for sepsis

    Research output: Contribution to journalReviewpeer-review

  3. Does rocking motion calm delirious patients in ICU? A multicentre randomised clinical trial protocol (RockingICU)

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Iatrogenic withdrawal syndrome frequently occurs in paediatric intensive care without algorithm for tapering of analgosedation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Is clinical heterogeneity the foremost prominent threat to the validity of meta-analyses?

    Research output: Contribution to journalEditorialpeer-review

  1. Acute Postoperative Pain Trajectory Groups: Comment

    Research output: Contribution to journalLetterpeer-review

  2. Enhanced recovery after breast reconstruction with a pedicled Latissimus Dorsi flap-A prospective clinical study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: The main disease etiologies requiring emergency high-risk abdominal surgery are intestinal obstruction and perforated viscus and the differences in immune response to these pathologies are largely unexplored. In search of improvement of patient assessment in the perioperative phase, we examined the inflammatory response in this setting, focusing on potential difference in pathophysiology. Methods: The electronic medical records of 487 patients who underwent emergency abdominal surgery from year 2013-2015 for intestinal obstruction and perforated viscus were reviewed. We evaluated the relationship between pre- and postoperative C-reactive protein (CRP) trajectory, fluid balance, and perioperative morbidity and mortality according to type of surgery, intervention, and surgical pathology. Results: A total of 418 patients were included. Pre- and postoperative absolute CRP values were significantly higher in patients with perforated viscus (n = 203) than in intestinal obstruction (n = 215) (P <.0001). Relative changes at hour 6 and POD 1 were non-significant (P =.716 and P =.816 respectively). There was significant association between both pre- (quartile 1 vs 4, OR 5.11; P <.01) and postoperative (quartile 1 vs 4, OR 4.10; P <.001) CRP and adverse outcome, along with fluid balance and adverse outcome in patients with obstruction but not in those with perforation. Fluid balance and CRP had statistically significant positive correlation in patients with obstruction. Conclusions: In this explorative study, a high pre- and postoperative CRP and a high positive fluid balance were associated with worse outcome in patients with intestinal obstruction, but not in patients with perforated viscus. Future studies should address the different inflammatory and fluid trajectories in these specific pathologies.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Issue number6
Pages (from-to) 730-739
Number of pages9
Publication statusPublished - Jul 2021

Bibliographical note

© 2021 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

    Research areas

  • emergency laparotomy, inflammation, pathophysiology, resuscitation fluids

ID: 62019589