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Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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@article{0307c03e6f8142859ae3d5f021c41d91,
title = "Inflammatory markers of CHMP2B-mediated frontotemporal dementia",
abstract = "Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.",
author = "Peter Roos and {von Essen}, {Marina Rode} and Nielsen, {Troels Tolstrup} and Peter Johannsen and Jette Stokholm and Bie, {Anne Sigaard} and Gunhild Waldemar and Simonsen, {Anja Hviid} and Amanda Heslegrave and Henrik Zetterberg and Finn Sellebjerg and Nielsen, {J{\o}rgen Erik} and {FReJA Consortium}",
note = "Copyright {\textcopyright} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = nov,
day = "15",
doi = "10.1016/j.jneuroim.2018.08.009",
language = "English",
volume = "324",
pages = "136--142",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Inflammatory markers of CHMP2B-mediated frontotemporal dementia

AU - Roos, Peter

AU - von Essen, Marina Rode

AU - Nielsen, Troels Tolstrup

AU - Johannsen, Peter

AU - Stokholm, Jette

AU - Bie, Anne Sigaard

AU - Waldemar, Gunhild

AU - Simonsen, Anja Hviid

AU - Heslegrave, Amanda

AU - Zetterberg, Henrik

AU - Sellebjerg, Finn

AU - Nielsen, Jørgen Erik

AU - FReJA Consortium

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/11/15

Y1 - 2018/11/15

N2 - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

AB - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

U2 - 10.1016/j.jneuroim.2018.08.009

DO - 10.1016/j.jneuroim.2018.08.009

M3 - Journal article

C2 - 30193769

VL - 324

SP - 136

EP - 142

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -

ID: 55492249