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Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume324
Pages (from-to)136-142
Number of pages7
ISSN0165-5728
DOIs
Publication statusPublished - 15 Nov 2018

ID: 55492249