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Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review

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@article{1ee13740bdb545488c17eb8f341daa1f,
title = "Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review",
abstract = "Objective: The aim of this systematic review was to evaluate existing literature on inflammatory markers in CSF from patients with hydrocephalus and identify potential markers capable of promoting hydrocephalus development and progression.Methods: Relevant studies published before December 3rd 2020 were identified from PubMed, Embase, and reference lists. Studies were screened for eligibility using the predefined inclusion and exclusion criteria. Data from eligible studies were extracted, and sources of bias were evaluated. We included articles written in English investigating inflammatory markers in CSF from patients with hydrocephalus and control subjects. The review was conducted according to the PRISMA guidelines by three independent reviewers.Results: Twenty-two studies analyzed CSF from 311 patients with idiopathic normal pressure hydrocephalus (iNPH), 178 with posthemorrhagic hydrocephalus (PHH), 151 with other hydrocephalus diagnoses, and 394 control subjects. Fifty-eight inflammatory markers were investigated. The CSF of iNPH patients had increased CSF levels of IL-6, IL-1β, and LRG compared with control subjects, whereas the CSF of PHH patients had increased levels of IL-6, IL-18, and VEGF. CSF from patients with {"}other hydrocephalus diagnoses{"} had elevated IFN-γ compared to control subjects, and VEGF was increased in congenital hydrocephalus, spina bifida, and hydrocephalus associated with tuberculous meningitis compared with controls.Conclusion: IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.",
keywords = "Biomarkers/cerebrospinal fluid, Case-Control Studies, Disease Progression, Female, Gene Expression Regulation, Glycoproteins/cerebrospinal fluid, Humans, Hydrocephalus/cerebrospinal fluid, Inflammation, Interferon-gamma/cerebrospinal fluid, Interleukin-18/cerebrospinal fluid, Interleukin-1beta/cerebrospinal fluid, Interleukin-6/cerebrospinal fluid, Male, Signal Transduction, Vascular Endothelial Growth Factor A/cerebrospinal fluid",
author = "Lolansen, {Sara Diana} and Nina Rostgaard and Oernbo, {Eva Kjer} and Marianne Juhler and Simonsen, {Anja Hviid} and Nanna MacAulay",
note = "Copyright {\textcopyright} 2021 Sara Diana Lolansen et al.",
year = "2021",
doi = "10.1155/2021/8834822",
language = "English",
volume = "2021",
pages = "8834822",
journal = "Disease Markers",
issn = "0278-0240",
publisher = "I O S Press",

}

RIS

TY - JOUR

T1 - Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus

T2 - A Systematic Literature Review

AU - Lolansen, Sara Diana

AU - Rostgaard, Nina

AU - Oernbo, Eva Kjer

AU - Juhler, Marianne

AU - Simonsen, Anja Hviid

AU - MacAulay, Nanna

N1 - Copyright © 2021 Sara Diana Lolansen et al.

PY - 2021

Y1 - 2021

N2 - Objective: The aim of this systematic review was to evaluate existing literature on inflammatory markers in CSF from patients with hydrocephalus and identify potential markers capable of promoting hydrocephalus development and progression.Methods: Relevant studies published before December 3rd 2020 were identified from PubMed, Embase, and reference lists. Studies were screened for eligibility using the predefined inclusion and exclusion criteria. Data from eligible studies were extracted, and sources of bias were evaluated. We included articles written in English investigating inflammatory markers in CSF from patients with hydrocephalus and control subjects. The review was conducted according to the PRISMA guidelines by three independent reviewers.Results: Twenty-two studies analyzed CSF from 311 patients with idiopathic normal pressure hydrocephalus (iNPH), 178 with posthemorrhagic hydrocephalus (PHH), 151 with other hydrocephalus diagnoses, and 394 control subjects. Fifty-eight inflammatory markers were investigated. The CSF of iNPH patients had increased CSF levels of IL-6, IL-1β, and LRG compared with control subjects, whereas the CSF of PHH patients had increased levels of IL-6, IL-18, and VEGF. CSF from patients with "other hydrocephalus diagnoses" had elevated IFN-γ compared to control subjects, and VEGF was increased in congenital hydrocephalus, spina bifida, and hydrocephalus associated with tuberculous meningitis compared with controls.Conclusion: IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.

AB - Objective: The aim of this systematic review was to evaluate existing literature on inflammatory markers in CSF from patients with hydrocephalus and identify potential markers capable of promoting hydrocephalus development and progression.Methods: Relevant studies published before December 3rd 2020 were identified from PubMed, Embase, and reference lists. Studies were screened for eligibility using the predefined inclusion and exclusion criteria. Data from eligible studies were extracted, and sources of bias were evaluated. We included articles written in English investigating inflammatory markers in CSF from patients with hydrocephalus and control subjects. The review was conducted according to the PRISMA guidelines by three independent reviewers.Results: Twenty-two studies analyzed CSF from 311 patients with idiopathic normal pressure hydrocephalus (iNPH), 178 with posthemorrhagic hydrocephalus (PHH), 151 with other hydrocephalus diagnoses, and 394 control subjects. Fifty-eight inflammatory markers were investigated. The CSF of iNPH patients had increased CSF levels of IL-6, IL-1β, and LRG compared with control subjects, whereas the CSF of PHH patients had increased levels of IL-6, IL-18, and VEGF. CSF from patients with "other hydrocephalus diagnoses" had elevated IFN-γ compared to control subjects, and VEGF was increased in congenital hydrocephalus, spina bifida, and hydrocephalus associated with tuberculous meningitis compared with controls.Conclusion: IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.

KW - Biomarkers/cerebrospinal fluid

KW - Case-Control Studies

KW - Disease Progression

KW - Female

KW - Gene Expression Regulation

KW - Glycoproteins/cerebrospinal fluid

KW - Humans

KW - Hydrocephalus/cerebrospinal fluid

KW - Inflammation

KW - Interferon-gamma/cerebrospinal fluid

KW - Interleukin-18/cerebrospinal fluid

KW - Interleukin-1beta/cerebrospinal fluid

KW - Interleukin-6/cerebrospinal fluid

KW - Male

KW - Signal Transduction

KW - Vascular Endothelial Growth Factor A/cerebrospinal fluid

UR - http://www.scopus.com/inward/record.url?scp=85100897680&partnerID=8YFLogxK

U2 - 10.1155/2021/8834822

DO - 10.1155/2021/8834822

M3 - Review

C2 - 33613789

VL - 2021

SP - 8834822

JO - Disease Markers

JF - Disease Markers

SN - 0278-0240

M1 - 8834822

ER -

ID: 64685769