Inflammatory human leucocyte antigen genotypes are not a risk factor in chronic subdural hematoma development

Thorbjørn Søren Rønn Jensen*, Kåre Fugleholm, Claus Thorn Ekstrøm, Helle Bruunsgaard

*Corresponding author for this work


BACKGROUND: Chronic subdural hematoma (CSDH) pathophysiology has undergone a paradigm shift from being regarded as solely traumatic to be driven mainly by inflammation. Human leucocyte antigen (HLA) is a gene complex involved in antigen processing and presentation to T lymphocytes, thereby mediating the adaptive immune responses. As specific HLA profiles are associated with inflammatory diseases, patients with a specific HLA profile may have a lower threshold for subdural inflammation, and therefore are predisposed for CSDH development. We hypothesized that (1) CSDH patients have a specific HLA profile compared to a Danish background population, and (2) patients with recurrent CSDH have a specific HLA profile compared to CSDH patients without recurrent CSDH.

METHODS: Three specific HLA class II haplotypes known to drive inflammatory-mediated diseases were determined in 68 patients with CSDH. The distribution of these three haplotypes in our CSDH population was compared to a Danish population of blood donors using Monte Carlo Pearson's chi-square test. Furthermore, the distribution of the haplotypes was compared between CSDH patients with and without recurrent CSDH.

RESULTS: We found no significant association between either of the haplotypes and the risk of CSDH, and neither of the haplotypes were associated with increased risk of CSDH recurrence.

CONCLUSION: This study did not show an association between selected HLA class II haplotypes and the risk of CSDH or recurrence of CSDH compared with a healthy background population.

Original languageEnglish
JournalActa Neurochirurgica
Issue number9
Pages (from-to)2399-2405
Number of pages7
Publication statusPublished - Sept 2023


  • Genotype
  • Hematoma, Subdural, Chronic/genetics
  • Humans
  • Inflammation
  • Recurrence
  • Retrospective Studies
  • Risk Factors
  • Subdural Space
  • Genetic disposition
  • Chronic subdural hematoma
  • Human leucocyte antigen


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