Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

Špela Šuler Baglama; Anja Trajber Horvat; Irena Peteln; Gregor Borut Ernst Jemec

doi:10.1159/000528128

Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

Špela Šuler Baglama^*, Anja Trajber Horvat, Irena Peteln, Gregor Borut Ernst Jemec

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

Original language	English
Journal	Case Reports in Dermatology
Volume	14
Issue number	3
Pages (from-to)	362-367
Number of pages	6
ISSN	1662-6567
DOIs	https://doi.org/10.1159/000528128
Publication status	Published - 7 Dec 2022
Externally published	Yes

Keywords

Actinic keratoses
Carboplatin
Chemotherapy
Inflammation
Paclitaxel

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10.1159/000528128

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title = "Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports",

abstract = "The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.",

keywords = "Actinic keratoses, Carboplatin, Chemotherapy, Inflammation, Paclitaxel",

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T1 - Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel

T2 - Two Case Reports

AU - Baglama, Špela Šuler

AU - Trajber Horvat, Anja

AU - Peteln, Irena

AU - Jemec, Gregor Borut Ernst

PY - 2022/12/7

Y1 - 2022/12/7

N2 - The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

AB - The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

KW - Actinic keratoses

KW - Carboplatin

KW - Chemotherapy

KW - Inflammation

KW - Paclitaxel

UR - https://www.scopus.com/pages/publications/85144206258

U2 - 10.1159/000528128

DO - 10.1159/000528128

M3 - Journal article

AN - SCOPUS:85144206258

SN - 1662-6567

VL - 14

SP - 362

EP - 367

JO - Case Reports in Dermatology

JF - Case Reports in Dermatology

IS - 3

ER -

Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

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