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Inflammation induced PD-L1-specific T cells

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@article{a801c5a51ff5463db34f8945042dd825,
title = "Inflammation induced PD-L1-specific T cells",
abstract = "PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as in healthy donors. It is well described that the expression of the PD-L1 protein is introduced in cells by pro-inflammatory cytokines, e.g. IFN-γ. In the current study, we were able to directly link inflammation with PD-L1-specific T cells by showing that inflammatory mediators such as IFN-γ generate measurable numbers of PD-L1-specific T cells in human PBMCs as well as in in vivo models. These PD-L1-specific T cells can vigorously modulate the cell compartments of the local environment. PD-L1-specific T cells may be important for immune homeostasis by sustaining the ongoing inflammatory response by the suppression of regulatory cell function both directly and indirectly.",
author = "Shamaila Munir and Lundsager, {Mia Thorup} and J{\o}rgensen, {Mia Aabroe} and Morten Hansen and Petersen, {Trine Hilkj{\ae}r} and Bonefeld, {Charlotte Menne} and Christina Friese and {\"O}zcan Met and Straten, {Per Thor} and Andersen, {Mads Hald}",
note = "Copyright: {\textcopyright} 2019 Munir et al.",
year = "2019",
month = sep,
day = "13",
doi = "10.15698/cst2019.10.201",
language = "English",
volume = "3",
pages = "319--327",
journal = "Cell stress",
issn = "2523-0204",
publisher = "Shared Science Publishers OG",
number = "10",

}

RIS

TY - JOUR

T1 - Inflammation induced PD-L1-specific T cells

AU - Munir, Shamaila

AU - Lundsager, Mia Thorup

AU - Jørgensen, Mia Aabroe

AU - Hansen, Morten

AU - Petersen, Trine Hilkjær

AU - Bonefeld, Charlotte Menne

AU - Friese, Christina

AU - Met, Özcan

AU - Straten, Per Thor

AU - Andersen, Mads Hald

N1 - Copyright: © 2019 Munir et al.

PY - 2019/9/13

Y1 - 2019/9/13

N2 - PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as in healthy donors. It is well described that the expression of the PD-L1 protein is introduced in cells by pro-inflammatory cytokines, e.g. IFN-γ. In the current study, we were able to directly link inflammation with PD-L1-specific T cells by showing that inflammatory mediators such as IFN-γ generate measurable numbers of PD-L1-specific T cells in human PBMCs as well as in in vivo models. These PD-L1-specific T cells can vigorously modulate the cell compartments of the local environment. PD-L1-specific T cells may be important for immune homeostasis by sustaining the ongoing inflammatory response by the suppression of regulatory cell function both directly and indirectly.

AB - PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as in healthy donors. It is well described that the expression of the PD-L1 protein is introduced in cells by pro-inflammatory cytokines, e.g. IFN-γ. In the current study, we were able to directly link inflammation with PD-L1-specific T cells by showing that inflammatory mediators such as IFN-γ generate measurable numbers of PD-L1-specific T cells in human PBMCs as well as in in vivo models. These PD-L1-specific T cells can vigorously modulate the cell compartments of the local environment. PD-L1-specific T cells may be important for immune homeostasis by sustaining the ongoing inflammatory response by the suppression of regulatory cell function both directly and indirectly.

U2 - 10.15698/cst2019.10.201

DO - 10.15698/cst2019.10.201

M3 - Journal article

C2 - 31656949

VL - 3

SP - 319

EP - 327

JO - Cell stress

JF - Cell stress

SN - 2523-0204

IS - 10

ER -

ID: 58521523