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Inflammation in Traumatic Brain Injury

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  • Teodor T Postolache
  • Abhishek Wadhawan
  • Adem Can
  • Christopher A Lowry
  • Margaret Woodbury
  • Hina Makkar
  • Andrew J Hoisington
  • Alison J Scott
  • Eileen Potocki
  • Michael E Benros
  • John W Stiller
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There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.

Original languageEnglish
JournalJournal of Alzheimer's Disease
Volume74
Issue number1
Pages (from-to)1-28
Number of pages28
ISSN1387-2877
DOIs
Publication statusPublished - 2020

    Research areas

  • Depression, glia, immune challenge, immunomodulation, inflammation, priming, probiotic, traumatic brain injury

ID: 59581962