Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Infective endocarditis in right ventricular outflow tract conduits: a register-based comparison of homografts, Contegra grafts and Melody transcatheter valves

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Blood pressure and brain injury in cardiac surgery: a secondary analysis of a randomized trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. 2019 EACTS Expert Consensus on long-term mechanical circulatory support

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Intraoperative flow profiles of arterial and venous bypass grafts to the left coronary territory

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Lung transplantation after ex vivo lung perfusion in two Scandinavian centres

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Vascular function in adults with cyanotic congenital heart disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Left-sided heart disease and risk of death in patients with end-stage kidney disease receiving haemodialysis: an observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Implications of hydrodynamic testing to guide sizing of self-expanding transcatheter heart valves for valve-in-valve procedures

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Performance of the TRUE dilatation balloon valvuloplasty catheter beyond rated burst pressure: A bench study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Early and late risk of ischemic stroke after TAVR as compared to a nationwide background population

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVES: The aim was to investigate the incidence of infective endocarditis (IE) in right ventricle-to-pulmonary artery conduits implanted at a Danish tertiary centre.

METHODS: Cases of IE in patients with homografts, Contegra grafts and Melody transcatheter valves were evaluated retrospectively with regard to the likeliness of the diagnosis using the modified Duke criteria and the likeliness of conduit involvement. Incidence rates for IE were calculated 1 and 5 years after valve implantation for all 3 conduits, and separately for Melody subgroups depending on which conduit served as landing zone. Cox regression with time-dependent covariates was used to model the impact of the conduit type on the incidence of IE.

RESULTS: Annualized incidence rates of IE in homografts, Contegra grafts and Melody valves were 0.40% (0.40 cases per 100 patient-years), 0.97% and 6.96% 1 year and 0.27%, 1.12% and 2.89% 5 years after valve implantation. Hazard ratios (HRs) were 3.20 [95% confidence interval (CI) 0.91-11.17, P = 0.069] for Contegra grafts and 11.89 (95% CI 2.91-48.48, P < 0.001) for Melody valves compared to homografts.

CONCLUSIONS: Bovine pulmonary conduits were more prone to endocarditis, with Melody valves being the most frequently infected. HRs for the risk of suffering from endocarditis were substantially higher for Melody valves and Contegra grafts compared to homografts, although this finding was only statistically significant for Melody valves and not for Contegra grafts.

Original languageEnglish
JournalEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Volume56
Issue number1
Pages (from-to)87-93
Number of pages7
ISSN1010-7940
DOIs
Publication statusPublished - 1 Jul 2019

ID: 59122741