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Infectious mononucleosis as a risk factor for depression: a nationwide cohort study

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@article{98862f50be1b4ee8a1bacb4688fe6f62,
title = "Infectious mononucleosis as a risk factor for depression: a nationwide cohort study",
abstract = "BACKGROUND: Infectious mononucleosis is a clinical diagnosis characterized by fever, sore throat, lymph node enlargement and often prolonged fatigue, most commonly caused by Epstein-Barr virus infection. Previous studies have indicated that infectious mononucleosis can be followed by depression; however, large-scale studies are lacking. We used nationwide registry data to investigate the association between infectious mononucleosis and subsequent depression in this first large-scale study.METHODS: Prospective cohort study using nationwide Danish registers covering all 1,440,590 singletons born (1977-2005) in Denmark by Danish born parents (21,830,542 person-years' follow-up until 2016); where 12,510 individuals had a hospital contact with infectious mononucleosis. The main outcome measures were a diagnosis of major depressive disorder (ICD-8: 296.09, 298.09, 300.4; ICD-10: F32) requiring hospital contact.RESULTS: Infectious mononucleosis was associated with a 40% increased hazard ratio (HR) for a subsequent depression diagnosis in the fully adjusted model (HR: 1.40, 95% CI: 1.26-1.56;n=358), when compared to unexposed individuals. The increased risk of being diagnosed with depression was significant to the periods one to four years after the infectious mononucleosis diagnosis (HR: 1.40, 95% CI: 1.17-1.67;n=121) and ≥ five years (HR: 1.40, 95% CI: 1.22-1.61;n=207). We did not find any differences according to age (p=0.61) nor sex (p=0.30).CONCLUSION: In this largest study to date, infectious mononucleosis in childhood or adolescence was associated with an increased risk of a subsequent depression. Our findings have important clinical implications and identifies youth with infectious mononucleosis as a group at high risk of later depression in young adulthood.",
keywords = "Depression, Epidemiology, Epstein-Barr virus, Infectious mononucleosis, Psychiatry",
author = "Nina Vindegaard and Petersen, {Liselotte Vogdrup} and {Ingrid Lyng-Rasmussen}, Bodil and S{\o}ren Dalsgaard and {Eriksen Benros}, Michael",
note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",
year = "2021",
month = may,
doi = "10.1016/j.bbi.2021.01.035",
language = "English",
volume = "94",
pages = "259--265",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Infectious mononucleosis as a risk factor for depression

T2 - a nationwide cohort study

AU - Vindegaard, Nina

AU - Petersen, Liselotte Vogdrup

AU - Ingrid Lyng-Rasmussen, Bodil

AU - Dalsgaard, Søren

AU - Eriksen Benros, Michael

N1 - Copyright © 2021. Published by Elsevier Inc.

PY - 2021/5

Y1 - 2021/5

N2 - BACKGROUND: Infectious mononucleosis is a clinical diagnosis characterized by fever, sore throat, lymph node enlargement and often prolonged fatigue, most commonly caused by Epstein-Barr virus infection. Previous studies have indicated that infectious mononucleosis can be followed by depression; however, large-scale studies are lacking. We used nationwide registry data to investigate the association between infectious mononucleosis and subsequent depression in this first large-scale study.METHODS: Prospective cohort study using nationwide Danish registers covering all 1,440,590 singletons born (1977-2005) in Denmark by Danish born parents (21,830,542 person-years' follow-up until 2016); where 12,510 individuals had a hospital contact with infectious mononucleosis. The main outcome measures were a diagnosis of major depressive disorder (ICD-8: 296.09, 298.09, 300.4; ICD-10: F32) requiring hospital contact.RESULTS: Infectious mononucleosis was associated with a 40% increased hazard ratio (HR) for a subsequent depression diagnosis in the fully adjusted model (HR: 1.40, 95% CI: 1.26-1.56;n=358), when compared to unexposed individuals. The increased risk of being diagnosed with depression was significant to the periods one to four years after the infectious mononucleosis diagnosis (HR: 1.40, 95% CI: 1.17-1.67;n=121) and ≥ five years (HR: 1.40, 95% CI: 1.22-1.61;n=207). We did not find any differences according to age (p=0.61) nor sex (p=0.30).CONCLUSION: In this largest study to date, infectious mononucleosis in childhood or adolescence was associated with an increased risk of a subsequent depression. Our findings have important clinical implications and identifies youth with infectious mononucleosis as a group at high risk of later depression in young adulthood.

AB - BACKGROUND: Infectious mononucleosis is a clinical diagnosis characterized by fever, sore throat, lymph node enlargement and often prolonged fatigue, most commonly caused by Epstein-Barr virus infection. Previous studies have indicated that infectious mononucleosis can be followed by depression; however, large-scale studies are lacking. We used nationwide registry data to investigate the association between infectious mononucleosis and subsequent depression in this first large-scale study.METHODS: Prospective cohort study using nationwide Danish registers covering all 1,440,590 singletons born (1977-2005) in Denmark by Danish born parents (21,830,542 person-years' follow-up until 2016); where 12,510 individuals had a hospital contact with infectious mononucleosis. The main outcome measures were a diagnosis of major depressive disorder (ICD-8: 296.09, 298.09, 300.4; ICD-10: F32) requiring hospital contact.RESULTS: Infectious mononucleosis was associated with a 40% increased hazard ratio (HR) for a subsequent depression diagnosis in the fully adjusted model (HR: 1.40, 95% CI: 1.26-1.56;n=358), when compared to unexposed individuals. The increased risk of being diagnosed with depression was significant to the periods one to four years after the infectious mononucleosis diagnosis (HR: 1.40, 95% CI: 1.17-1.67;n=121) and ≥ five years (HR: 1.40, 95% CI: 1.22-1.61;n=207). We did not find any differences according to age (p=0.61) nor sex (p=0.30).CONCLUSION: In this largest study to date, infectious mononucleosis in childhood or adolescence was associated with an increased risk of a subsequent depression. Our findings have important clinical implications and identifies youth with infectious mononucleosis as a group at high risk of later depression in young adulthood.

KW - Depression

KW - Epidemiology

KW - Epstein-Barr virus

KW - Infectious mononucleosis

KW - Psychiatry

UR - http://www.scopus.com/inward/record.url?scp=85101139841&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2021.01.035

DO - 10.1016/j.bbi.2021.01.035

M3 - Journal article

C2 - 33571632

VL - 94

SP - 259

EP - 265

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

ER -

ID: 62297061