Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland

H. Shen; K. M. Main; A. M. Andersson; I. N. Damgaard; H. E. Virtanen; N. E. Skakkebaek; J. Toppari; K. W. Schramm

doi:10.2495/ETOX080051

Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland

H. Shen^*, K. M. Main, A. M. Andersson, I. N. Damgaard, H. E. Virtanen, N. E. Skakkebaek, J. Toppari, K. W. Schramm

^*Corresponding author for this work

1 Citation (Scopus)

Abstract

Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.

Original language	English
Title of host publication	Environmental Toxicology II
Number of pages	8
Volume	110
Publisher	WITPress
Publication date	1 Jan 2008
Pages	45-52
ISBN (Print)	9781845641146
DOIs	https://doi.org/10.2495/ETOX080051
Publication status	Published - 1 Jan 2008
Event	2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008 - Granada, Portugal Duration: 4 Jun 2008 → 6 Jun 2008

Conference

Conference	2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008
Country/Territory	Portugal
City	Granada
Period	04/06/2008 → 06/06/2008
Sponsor	WIT Transactions on Ecology and the Environment

Keywords

Breast milk
Infants
Organobromine compounds
Organochlorine pesticides
Placenta

Access to Document

10.2495/ETOX080051

Cite this

Shen, H, Main, KM , Andersson, AM, Damgaard, IN, Virtanen, HE, Skakkebaek, NE, Toppari, J & Schramm, KW 2008, Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland. in Environmental Toxicology II. vol. 110, WITPress, pp. 45-52, 2nd International Conference on Environmental Toxicology, Environmental Toxicology 2008, Granada, Portugal, 04/06/2008. https://doi.org/10.2495/ETOX080051

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abstract = "Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.",

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AU - Shen, H.

AU - Main, K. M.

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AU - Damgaard, I. N.

AU - Virtanen, H. E.

AU - Skakkebaek, N. E.

AU - Toppari, J.

AU - Schramm, K. W.

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N2 - Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.

AB - Significantly poorer male reproductive health has been documented in Danish compared to Finnish men, including a higher prevalence of cryptorchidism and hypospadias. Exposure to environmental pollutants with endocrine disrupting activities has been suggested as a possible contributing factor. In this study, we investigated whether there was a difference in milk and placenta concentrations of persistent organohalogen compounds between the two countries. Organohalogens were analyzed by high-resolution gas chromatography-high resolution mass spectrometry in human milk samples from Finland (n65) and Denmark (n65) and placentas (n168 Danish, 112 Finnish), selected from a population-based cohort. p, p-DDE was the dominant pollutant. β-HCH, HCB, END-I, dieldrin, OXC, c-HE, and p, p-DDT were the other main organochlorines detected. Danish samples had significantly higher concentrations of p, p-DDE, p, p-DDT, β-HCH, HCB, dieldrin, c-HE, and OXC than Finnish. The organochlorine levels were higher in Danish samples, which suggests higher exposure of Danish infants.

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KW - Infants

KW - Organobromine compounds

KW - Organochlorine pesticides

KW - Placenta

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ER -

Infant exposure to persistent organochlorine compounds is higher in Denmark than in Finland

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