Abstract
Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.
| Original language | English |
|---|---|
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 35 |
| Issue number | 5 |
| Pages (from-to) | 1008-10 |
| Number of pages | 3 |
| ISSN | 0066-4804 |
| DOIs | |
| Publication status | Published - May 1991 |
| Externally published | Yes |
Keywords
- Culture Media
- Enzyme Induction/drug effects
- Hydrogen-Ion Concentration
- Imipenem/pharmacology
- Microbial Sensitivity Tests
- Piperacillin/pharmacology
- Pseudomonas aeruginosa/enzymology
- beta-Lactamases/biosynthesis
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