Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia

Natakarn Nimsanor; Ida Jørring; Mikkel A Rasmussen; Christian Clausen; Ulrike A Mau-Holzmann; Narisorn Kitiyanant; Jørgen E Nielsen; Troels T Nielsen; Poul Hyttel; Bjørn Holst; Benjamin Schmid

doi:10.1016/j.scr.2016.10.006

Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia

Natakarn Nimsanor, Ida Jørring, Mikkel A Rasmussen, Christian Clausen, Ulrike A Mau-Holzmann, Narisorn Kitiyanant, Jørgen E Nielsen, Troels T Nielsen, Poul Hyttel, Bjørn Holst, Benjamin Schmid

Department of Neurology

5 Citations (Scopus)

Abstract

Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the gene coding the microtubule-associated protein tau (MAPT) can cause FTDP-17 but the underlying mechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required neuronal cell type. Here, we report the generation of iPSCs from a 44-year-old symptomatic woman carrying a S305I mutation in the MAPT-gene.

Original language	English
Journal	Stem Cell Research
Volume	17
Issue number	3
Pages (from-to)	564-567
Number of pages	4
ISSN	1873-5061
DOIs	https://doi.org/10.1016/j.scr.2016.10.006
Publication status	Published - 20 Oct 2016

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Nimsanor, N., Jørring, I., Rasmussen, M. A., Clausen, C., Mau-Holzmann, U. A., Kitiyanant, N., Nielsen, J. E., Nielsen, T. T., Hyttel, P., Holst, B., & Schmid, B. (2016). Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. Stem Cell Research, 17(3), 564-567. https://doi.org/10.1016/j.scr.2016.10.006

Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. / Nimsanor, Natakarn; Jørring, Ida; Rasmussen, Mikkel A et al.
In: Stem Cell Research, Vol. 17, No. 3, 20.10.2016, p. 564-567.

Research output: Contribution to journal › Journal article › Research › peer-review

Nimsanor, N, Jørring, I, Rasmussen, MA, Clausen, C, Mau-Holzmann, UA, Kitiyanant, N, Nielsen, JE , Nielsen, TT, Hyttel, P, Holst, B & Schmid, B 2016, 'Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia', Stem Cell Research, vol. 17, no. 3, pp. 564-567. https://doi.org/10.1016/j.scr.2016.10.006

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abstract = "Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the gene coding the microtubule-associated protein tau (MAPT) can cause FTDP-17 but the underlying mechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required neuronal cell type. Here, we report the generation of iPSCs from a 44-year-old symptomatic woman carrying a S305I mutation in the MAPT-gene.",

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AU - Clausen, Christian

AU - Mau-Holzmann, Ulrike A

AU - Kitiyanant, Narisorn

AU - Nielsen, Jørgen E

AU - Nielsen, Troels T

AU - Hyttel, Poul

AU - Holst, Bjørn

AU - Schmid, Benjamin

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Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia

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