Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

D B Pedersen; T Eysteinsson; E Stefánsson; Jens Folke Kiilgaard; M La Cour; K Bang; P K Jensen

doi:10.1136/bjo.2003.041251

Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

D B Pedersen, T Eysteinsson, E Stefánsson, Jens Folke Kiilgaard, M La Cour, K Bang, P K Jensen

Department of Ophthalmology

9 Citations (Scopus)

Abstract

Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.

Original language	English
Journal	British Journal of Ophthalmology
Volume	88
Issue number	8
Pages (from-to)	1088-91
Number of pages	4
ISSN	0007-1161
DOIs	https://doi.org/10.1136/bjo.2003.041251
Publication status	Published - 2004

Keywords

Animals
Carbon Dioxide
Carbonic Anhydrase Inhibitors
Cyclooxygenase Inhibitors
Indomethacin
Optic Nerve
Oxygen
Swine

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10.1136/bjo.2003.041251

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title = "Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing",

abstract = "Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.",

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language = "English",

volume = "88",

pages = "1088--91",

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T1 - Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

AU - Pedersen, D B

AU - Eysteinsson, T

AU - Stefánsson, E

AU - Kiilgaard, Jens Folke

AU - La Cour, M

AU - Bang, K

AU - Jensen, P K

PY - 2004

Y1 - 2004

N2 - Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.

AB - Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig.

KW - Animals

KW - Carbon Dioxide

KW - Carbonic Anhydrase Inhibitors

KW - Cyclooxygenase Inhibitors

KW - Indomethacin

KW - Optic Nerve

KW - Oxygen

KW - Swine

UR - https://www.scopus.com/pages/publications/3543029278

U2 - 10.1136/bjo.2003.041251

DO - 10.1136/bjo.2003.041251

M3 - Journal article

C2 - 15258031

SN - 0007-1161

VL - 88

SP - 1088

EP - 1091

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

IS - 8

ER -

Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing

Abstract

Keywords

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