Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. High brain serotonin levels in migraine between attacks: A 5-HTreceptor binding PET study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Risk for affective disorders is associated with greater prefrontal gray matter volumes: A prospective longitudinal study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Accessibility of cortical regions to focal TES: Dependence on spatial position, safety, and practical constraints

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Neuroimaging Of Cold Allodynia Reveals A Central Disinhibition Mechanism Of Pain

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11.2 deletion. We recorded high-density EEG from 19 individuals with 22q11.2 deletion syndrome (12-25 years), as well as 27 healthy volunteers with comparable age and sex distribution, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Using posterior probability maps and dynamic causal modelling we tested three different models accounting for repetition dependent changes in cortical responses as well as in effective connectivity; namely an adaptation model, a prediction model, and a model including both adaptation and prediction. Repetition-dependent changes were parametrically modulated by a combination of adaptation and prediction and were apparent in both cortical responses and in the underlying effective connectivity. This effect was reduced in individuals with a 22q11.2 deletion and was negatively correlated with negative symptom severity. Follow-up analysis showed that the reduced effect of the combined adaptation and prediction model seen in individuals with 22q11.2 deletion was driven by reduced adaptation rather than prediction failure. Our findings suggest that adaptation is reduced in individuals with a 22q11.2 deletion, which can be interpreted in light of the framework of predictive coding as a failure to suppress prediction errors.

Original languageEnglish
JournalNeuroImage. Clinical
Volume22
Pages (from-to)101721
ISSN2213-1582
DOIs
Publication statusE-pub ahead of print - 13 Feb 2019

ID: 56746062