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Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D

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Harvard

Cashman, KD, Kiely, ME, Andersen, R, Grønborg, IM, Madsen, KH, Nissen, J, Tetens, I, Tripkovic, L, Lanham-New, SA, Toxqui, L, Vaquero, MP, Trautvetter, U, Jahreis, G, Mistry, VV, Specker, BL, Hower, J, Knoll, A, Wagner, D, Vieth, R, Öhlund, I, Karlsland Åkeson, P, Brett, NR, Weiler, HA & Ritz, C 2021, 'Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D', European Journal of Nutrition, vol. 60, no. 2, pp. 939-959. https://doi.org/10.1007/s00394-020-02298-x

APA

Cashman, K. D., Kiely, M. E., Andersen, R., Grønborg, I. M., Madsen, K. H., Nissen, J., Tetens, I., Tripkovic, L., Lanham-New, S. A., Toxqui, L., Vaquero, M. P., Trautvetter, U., Jahreis, G., Mistry, V. V., Specker, B. L., Hower, J., Knoll, A., Wagner, D., Vieth, R., ... Ritz, C. (2021). Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. European Journal of Nutrition, 60(2), 939-959. https://doi.org/10.1007/s00394-020-02298-x

CBE

Cashman KD, Kiely ME, Andersen R, Grønborg IM, Madsen KH, Nissen J, Tetens I, Tripkovic L, Lanham-New SA, Toxqui L, Vaquero MP, Trautvetter U, Jahreis G, Mistry VV, Specker BL, Hower J, Knoll A, Wagner D, Vieth R, Öhlund I, Karlsland Åkeson P, Brett NR, Weiler HA, Ritz C. 2021. Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. European Journal of Nutrition. 60(2):939-959. https://doi.org/10.1007/s00394-020-02298-x

MLA

Vancouver

Author

Cashman, Kevin D ; Kiely, Mairead E ; Andersen, Rikke ; Grønborg, Ida M ; Madsen, Katja H ; Nissen, Janna ; Tetens, Inge ; Tripkovic, Laura ; Lanham-New, Susan A ; Toxqui, Laura ; Vaquero, M Pilar ; Trautvetter, Ulrike ; Jahreis, Gerhard ; Mistry, Vikram V ; Specker, Bonny L ; Hower, Jürgen ; Knoll, Anette ; Wagner, Dennis ; Vieth, Reinhold ; Öhlund, Inger ; Karlsland Åkeson, Pia ; Brett, Neil R ; Weiler, Hope A ; Ritz, Christian. / Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D. In: European Journal of Nutrition. 2021 ; Vol. 60, No. 2. pp. 939-959.

Bibtex

@article{aab707eee283404589c4903bd3d4df41,
title = "Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D",
abstract = "CONTEXT AND PURPOSE: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.METHODS: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.RESULTS: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).CONCLUSIONS: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Dietary Supplements, Food, Fortified, Humans, Middle Aged, Reference Values, Vitamin D, Vitamin D Deficiency, Vitamins, Young Adult",
author = "Cashman, {Kevin D} and Kiely, {Mairead E} and Rikke Andersen and Gr{\o}nborg, {Ida M} and Madsen, {Katja H} and Janna Nissen and Inge Tetens and Laura Tripkovic and Lanham-New, {Susan A} and Laura Toxqui and Vaquero, {M Pilar} and Ulrike Trautvetter and Gerhard Jahreis and Mistry, {Vikram V} and Specker, {Bonny L} and J{\"u}rgen Hower and Anette Knoll and Dennis Wagner and Reinhold Vieth and Inger {\"O}hlund and {Karlsland {\AA}keson}, Pia and Brett, {Neil R} and Weiler, {Hope A} and Christian Ritz",
year = "2021",
month = mar,
doi = "10.1007/s00394-020-02298-x",
language = "English",
volume = "60",
pages = "939--959",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Dr. Dietrich/Steinkopff Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D

AU - Cashman, Kevin D

AU - Kiely, Mairead E

AU - Andersen, Rikke

AU - Grønborg, Ida M

AU - Madsen, Katja H

AU - Nissen, Janna

AU - Tetens, Inge

AU - Tripkovic, Laura

AU - Lanham-New, Susan A

AU - Toxqui, Laura

AU - Vaquero, M Pilar

AU - Trautvetter, Ulrike

AU - Jahreis, Gerhard

AU - Mistry, Vikram V

AU - Specker, Bonny L

AU - Hower, Jürgen

AU - Knoll, Anette

AU - Wagner, Dennis

AU - Vieth, Reinhold

AU - Öhlund, Inger

AU - Karlsland Åkeson, Pia

AU - Brett, Neil R

AU - Weiler, Hope A

AU - Ritz, Christian

PY - 2021/3

Y1 - 2021/3

N2 - CONTEXT AND PURPOSE: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.METHODS: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.RESULTS: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).CONCLUSIONS: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.

AB - CONTEXT AND PURPOSE: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.METHODS: IPD analysis using data from 1429 participants (ages 2-89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models.RESULTS: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI).CONCLUSIONS: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Child, Preschool

KW - Dietary Supplements

KW - Food, Fortified

KW - Humans

KW - Middle Aged

KW - Reference Values

KW - Vitamin D

KW - Vitamin D Deficiency

KW - Vitamins

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85086574425&partnerID=8YFLogxK

U2 - 10.1007/s00394-020-02298-x

DO - 10.1007/s00394-020-02298-x

M3 - Journal article

C2 - 32556447

VL - 60

SP - 939

EP - 959

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 2

ER -

ID: 74403119