Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Lars Nyberg; Micael Andersson; Anders Lundquist; William F C Baaré; David Bartrés-Faz; Lars Bertram; Carl-Johan Boraxbekk; Andreas M Brandmaier; Naiara Demnitz; Christian A Drevon; Sandra Duezel; Klaus P Ebmeier; Paolo Ghisletta; Richard Henson; Daria E A Jensen; Rogier A Kievit; Ethan Knights; Simone Kühn; Ulman Lindenberger; Anna Plachti; Sara Pudas; James M Roe; Kathrine Skak Madsen; Cristina Solé-Padullés; Yasmine Sommerer; Sana Suri; Enikő Zsoldos; Anders M Fjell; Kristine B Walhovd

doi:10.1093/cercor/bhac400

Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Lars Nyberg, Micael Andersson, Anders Lundquist, William F C Baaré, David Bartrés-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M Brandmaier, Naiara Demnitz, Christian A Drevon, Sandra Duezel, Klaus P Ebmeier, Paolo Ghisletta, Richard Henson, Daria E A Jensen, Rogier A Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Anna PlachtiSara Pudas, James M Roe, Kathrine Skak Madsen, Cristina Solé-Padullés, Yasmine Sommerer, Sana Suri, Enikő Zsoldos, Anders M Fjell, Kristine B Walhovd

9 Citations (Scopus)

Abstract

It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Original language	English
Journal	Cerebral Cortex
Volume	33
Issue number	9
Pages (from-to)	5075-5081
Number of pages	7
ISSN	1047-3211
DOIs	https://doi.org/10.1093/cercor/bhac400
Publication status	Published - 1 May 2023

Keywords

aging
caudate
cortex
hippocampus
individual differences

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Nyberg, L., Andersson, M., Lundquist, A., Baaré, W. F. C., Bartrés-Faz, D., Bertram, L., Boraxbekk, C.-J., Brandmaier, A. M., Demnitz, N., Drevon, C. A., Duezel, S., Ebmeier, K. P., Ghisletta, P., Henson, R., Jensen, D. E. A., Kievit, R. A., Knights, E., Kühn, S., Lindenberger, U., ... Walhovd, K. B. (2023). Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates. Cerebral Cortex, 33(9), 5075-5081. https://doi.org/10.1093/cercor/bhac400

Nyberg, L, Andersson, M, Lundquist, A, Baaré, WFC, Bartrés-Faz, D, Bertram, L, Boraxbekk, C-J, Brandmaier, AM, Demnitz, N, Drevon, CA, Duezel, S, Ebmeier, KP, Ghisletta, P, Henson, R, Jensen, DEA, Kievit, RA, Knights, E, Kühn, S, Lindenberger, U, Plachti, A, Pudas, S, Roe, JM, Madsen, KS, Solé-Padullés, C, Sommerer, Y, Suri, S, Zsoldos, E, Fjell, AM & Walhovd, KB 2023, 'Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates', Cerebral Cortex, vol. 33, no. 9, pp. 5075-5081. https://doi.org/10.1093/cercor/bhac400

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abstract = "It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.",

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AU - Boraxbekk, Carl-Johan

AU - Brandmaier, Andreas M

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AU - Drevon, Christian A

AU - Duezel, Sandra

AU - Ebmeier, Klaus P

AU - Ghisletta, Paolo

AU - Henson, Richard

AU - Jensen, Daria E A

AU - Kievit, Rogier A

AU - Knights, Ethan

AU - Kühn, Simone

AU - Lindenberger, Ulman

AU - Plachti, Anna

AU - Pudas, Sara

AU - Roe, James M

AU - Madsen, Kathrine Skak

AU - Solé-Padullés, Cristina

AU - Sommerer, Yasmine

AU - Suri, Sana

AU - Zsoldos, Enikő

AU - Fjell, Anders M

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Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

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Keywords

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