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Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin?

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  1. Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies

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  2. CD34+ cells in human intestine are fibroblasts adjacent to, but distinct from, interstitial cells of Cajal

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  3. Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells

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  4. Light- and electron microscopical studies of interstitial cells of Cajal and muscle cells at the submucosal border of human colon

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  1. Broadening risk profile in familial colorectal cancer type X; increased risk for five cancer types in the national Danish cohort

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  2. Difficult journeys in sarcoma care; socioeconomic disparity added to the multiple challenges of a rare tumor diagnosis

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  3. Meet the Acta Oncologica editorial board

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  4. Rational targeting of population groups and residential areas for colorectal cancer screening

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  • Ana Carneiro
  • Princy Francis
  • Pär-Ola Bendahl
  • Josefin Fernebro
  • Måns Akerman
  • Christopher Fletcher
  • Anders Rydholm
  • Ake Borg
  • Mef Nilbert
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Soft tissue sarcoma (STS) diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC arrays and gene expression profiling to 18 extremity soft tissue LMS and 31 extremity soft tissue UPS with the aim of identifying molecular subtype signatures and genomic prognostic markers. Both the gains/losses and gene expression signatures revealed striking similarities between UPS and LMS, which were indistinguishable using unsupervised hierarchical cluster analysis and significance analysis for microarrays. Gene expression analysis revealed just nine genes, among them tropomyosin beta, which were differentially expressed. Loss of 4q31 (encompassing the SMAD1 locus), loss of 18q22, and tumor necrosis were identified as independent predictors of metastasis in multivariate stepwise Cox regression analysis. Combined analysis applying loss of 4q31 and 18q22 and the presence of necrosis improved the area under receiver operating characteristic curve for metastasis prediction from 0.64 to 0.86. The extensive genetic similarities between extremity soft tissue UPS and LMS suggest a shared lineage of these STS subtypes and the new and independent genetic prognosticators identified hold promise for refined prognostic determination in high-grade, genetically complex STS.
Original languageEnglish
JournalLaboratory investigation; a journal of technical methods and pathology
Volume89
Issue number6
Pages (from-to)668-75
Number of pages7
DOIs
Publication statusPublished - 2009

    Research areas

  • Adult, Aged, Aged, 80 and over, Case-Control Studies, Chromosomes, Human, Cluster Analysis, Diagnosis, Differential, Gene Dosage, Gene Expression Profiling, Histiocytoma, Malignant Fibrous, Humans, Leiomyosarcoma, Liposarcoma, Middle Aged, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, Prognosis, Retrospective Studies, Tumor Markers, Biological

ID: 32543535