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Incretin mimetics: a novel therapeutic option for patients with type 2 diabetes - a review

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  1. Clinical potential of lixisenatide once daily treatment for type 2 diabetes mellitus

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  1. Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

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  2. Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

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  3. Prognostic value of ratio of transmitral early filling velocity to early diastolic strain rate in patients with Type 2 diabetes

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  4. The Liver-α-Cell Axis and Type 2 Diabetes

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  5. Evaluation of clinical translatability of the diet-induced obese and biopsy-confirmed gubra amylin mouse model of non-alcoholic steatohepatitis

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Type 2 diabetes mellitus is a metabolic disease associated with low quality of life and early death. The goal in diabetes treatment is to prevent these outcomes by tight glycemic control and minimizing vascular risk factors. So far, even intensified combination regimen with the traditional antidiabetes agents have failed to obtain these goals. Incretin mimetics are a new class of antidiabetes drugs which involve modulation of the incretin system. They bind to and activate glucagon-like peptide-1 (GLP-1) receptors on pancreatic beta-cells following which insulin secretion and synthesis are initiated. Since the compounds have no insulinotropic activity at lower glucose concentrations the risk of hypoglycemia - a well-known shortcoming of existing antidiabetes treatments - is low. Additionally, incretin mimetics have been shown to be associated with beneficial effects on cardiovascular risk factors such as weight loss, decrease in blood pressure and changes in lipid profile. Current clinical data on the two available incretin mimetics, exenatide and liraglutide, are evaluated in this review, focusing on pharmacology, efficacy, safety and tolerability. The review is built on a systematic PubMed and Medline search for publications with the key words GLP-1 receptor agonist, exenatide, liraglutide and type 2 diabetes mellitus up to January 2009.
Original languageEnglish
JournalDiabetes, Metabolic Syndrome and Obesity
Volume3
Pages (from-to)155-63
Number of pages9
ISSN1178-7007
Publication statusPublished - 1 Jan 2010

ID: 32266214