Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Increased vulnerability to Covid-19 in chronic kidney disease

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Response to letter regarding Tobacco smoking

    Research output: Contribution to journalLetterpeer-review

  2. Contribution of remnant cholesterol to cardiovascular risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Preheart failure comorbidities and impact on prognosis in heart failure patients: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The association between heart diseases and suicide: A nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Time Trends in Simple Congenital Heart Disease Over 39 Years: A Danish Nationwide Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Proposal for the use of echocardiography in bloodstream infections due to different streptococcal species

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hormone Replacement Therapy and Development of New Asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: The significance of chronic kidney disease on susceptibility to COVID-19 and subsequent outcomes remains unaddressed.

OBJECTIVE: To investigate the association of estimated glomerular filtration rate (eGFR) on risk of contracting COVID-19 and subsequent adverse outcomes.

METHODS: Rates of hospital-diagnosed COVID-19 were compared across strata of eGFR based on conditional logistic regression using a nested case-control framework with 1:4 matching of patients diagnosed with COVID-19 with controls from the Danish general population on age, gender, diabetes and hypertension. Risk of subsequent severe COVID-19 or death was assessed in a cohort study with comparisons across strata of eGFR based on adjusted Cox regression models with G-computation of results to determine 60-day risk standardized to the distribution of risk factors in the sample.

RESULTS: Estimated glomerular filtration rate was inversely associated with rate of hospital-diagnosed COVID-19: eGFR 61-90 mL/min/1.73m 2 HR 1.13 (95% CI 1.03-1.25), P = 0.011; eGFR 46-60 mL/min/1.73m 2 HR 1.26 (95% CI 1.06-1.50), P = 0.008; eGFR 31-45 mL/min/1.73m 2 HR 1.68 (95% CI 1.34-2.11), P < 0.001; and eGFR ≤ 30 mL/min/1.73m 2 3.33 (95% CI 2.50-4.42), P < 0.001 (eGFR > 90 mL/min/1.73m 2 as reference), and renal impairment was associated with progressive increase in standardized 60-day risk of death or severe COVID-19; eGFR > 90 mL/min/1.73m 2 13.9% (95% CI 9.7-15.0); eGFR 90-61 mL/min/1.73m 2 16.1% (95% CI 14.5-17.7); eGFR 46-60 mL/min/1.73m 2 17.8% (95% CI 14.7-21.2); eGFR 31-45 mL/min/1.73m 2 22.6% (95% CI 18.2-26.2); and eGFR ≤ 30 mL/min/1.73m 2 23.6% (95% CI 18.1-29.1).

CONCLUSIONS: Renal insufficiency was associated with progressive increase in both rate of hospital-diagnosed COVID-19 and subsequent risk of adverse outcomes. Results underscore a possible vulnerability associated with impaired renal function in relation to COVID-19.

Original languageEnglish
JournalJournal of Internal Medicine
Volume290
Issue number1
Pages (from-to)166-178
Number of pages13
ISSN0954-6820
DOIs
Publication statusPublished - Jul 2021

Bibliographical note

© 2021 Association for Publication of The Journal of Internal Medicine.

    Research areas

  • Adult, Aged, COVID-19/epidemiology, Case-Control Studies, Denmark/epidemiology, Disease Susceptibility, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Pandemics, Pneumonia, Viral/epidemiology, Renal Insufficiency, Chronic/complications, Retrospective Studies, Risk Factors, SARS-CoV-2, estimated glomerular filtration rate, renal insufficiency, COVID-19

ID: 61786873