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Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

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@article{41f79adc6e934a84b2e401a8c8c70408,
title = "Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load",
abstract = "New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.",
keywords = "Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, COVID-19/epidemiology, Child, Child, Preschool, Denmark/epidemiology, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, SARS-CoV-2, Viral Load, Young Adult",
author = "Lyngse, {Frederik Plesner} and K{\aa}re M{\o}lbak and Skov, {Robert Leo} and Christiansen, {Lasse Engbo} and Mortensen, {Laust Hvas} and Mads Albertsen and M{\o}ller, {Camilla Holten} and Krause, {Tyra Grove} and Morten Rasmussen and Michaelsen, {Thomas Yssing} and Marianne Voldstedlund and Jannik Fonager and Nina Steenhard and Kirkeby, {Carsten Thure} and {Danish Covid-19 Genome Consortium} and J{\o}rgensen, {Vibeke L.}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = dec,
day = "13",
doi = "10.1038/s41467-021-27202-x",
language = "English",
volume = "12",
pages = "7251",
journal = "Nature Communications",
issn = "2041-1722",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

AU - Lyngse, Frederik Plesner

AU - Mølbak, Kåre

AU - Skov, Robert Leo

AU - Christiansen, Lasse Engbo

AU - Mortensen, Laust Hvas

AU - Albertsen, Mads

AU - Møller, Camilla Holten

AU - Krause, Tyra Grove

AU - Rasmussen, Morten

AU - Michaelsen, Thomas Yssing

AU - Voldstedlund, Marianne

AU - Fonager, Jannik

AU - Steenhard, Nina

AU - Kirkeby, Carsten Thure

AU - Danish Covid-19 Genome Consortium

A2 - Jørgensen, Vibeke L.

N1 - © 2021. The Author(s).

PY - 2021/12/13

Y1 - 2021/12/13

N2 - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

AB - New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - COVID-19/epidemiology

KW - Child

KW - Child, Preschool

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Middle Aged

KW - SARS-CoV-2

KW - Viral Load

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85122774462&partnerID=8YFLogxK

U2 - 10.1038/s41467-021-27202-x

DO - 10.1038/s41467-021-27202-x

M3 - Journal article

C2 - 34903718

VL - 12

SP - 7251

JO - Nature Communications

JF - Nature Communications

SN - 2041-1722

IS - 1

ER -

ID: 73780259