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Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosis

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  1. Diagnostic value of oligoclonal bands in children: A Nationwide Population-Based Cohort Study

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  2. Dimethyl fumarate therapy suppresses B cell responses and follicular helper T cells in relapsing-remitting multiple sclerosis

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  3. Illegal cannabis use is common among Danes with multiple sclerosis

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CD154 (CD40-ligand, gp39), expressed on activated T cells, is crucial in T cell-dependent immune responses and may be involved in the pathogenesis of multiple sclerosis (MS). We studied cerebro-spinal fluid and peripheral blood T cell expression of CD154 in MS by flow cytometry. Patients with secondary progressive MS (SPMS) had constitutive CD154 expression on CD4 and CD8 T cells in blood. Constitutive CD154 expression was not observed in patients with relapsing-remitting MS (RRMS) or clinically isolated syndromes (CIS) suggestive of demyelinating disease. After ex vivo activation CD154 was, however, expressed on a higher percentage of T cells from patients with CIS or RRMS than from healthy control subjects. These results suggest involvement of CD154 in the pathogenesis of MS, and the shift from a relapsing-remitting to a secondary progressive disease course may be associated with constitutive, systemic CD154 expression.

Original languageEnglish
JournalEuropean journal of neurology : the official journal of the European Federation of Neurological Societies
Volume8
Issue number4
Pages (from-to)321-8
Number of pages8
ISSN1351-5101
Publication statusPublished - Jul 2001

    Research areas

  • Adult, Aged, Antigens, CD3, CD40 Ligand, Disease Progression, Female, Flow Cytometry, Humans, Immunoglobulins, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Oligoclonal Bands, T-Lymphocytes

ID: 45076737