Abstract
BACKGROUND AND PURPOSE: Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia.
METHODS: Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection.
RESULTS: 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43-6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years).
CONCLUSIONS: Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.
| Original language | English |
|---|---|
| Article number | 2 |
| Journal | European Journal of Neurology |
| Volume | 28 |
| Issue number | 2 |
| Pages (from-to) | 411-420 |
| Number of pages | 10 |
| ISSN | 1351-5101 |
| DOIs | |
| Publication status | Published - Feb 2021 |
Keywords
- dementia
- epidemiology
- infection
- mortality
- registry-based study
- based study
- registry‐